Caudate Volumetric Reductions Predicted by Carbohydrate-Deficient Transferrin in Patients with Alcohol Dependence

Shinwon Park; Jiyoung J. Jung; Ilhyang Kang; Boung Chul Lee; Suji L. Lee; Jiyoung Ma; Jungyoon Kim; Han Byul Cho; Hyeonseok S. Jeong; Soo Mee Lim; Young Sun Hong; Ihn Geun Choi; Jieun E. Kim

doi:10.1007/s11469-017-9803-6

Caudate Volumetric Reductions Predicted by Carbohydrate-Deficient Transferrin in Patients with Alcohol Dependence

Shinwon Park, Jiyoung J. Jung, Ilhyang Kang, Boung Chul Lee, Suji L. Lee, Jiyoung Ma, Jungyoon Kim, Han Byul Cho, Hyeonseok S. Jeong, Soo Mee Lim, Young Sun Hong, Ihn Geun Choi, Jieun E. Kim

Research output: Contribution to journal › Article › peer-review

Abstract

The caudate nucleus has shown a high relevance with substance craving and addiction in the pathophysiology of alcohol dependence. In this study, caudate volumetric deficits in patients with alcohol dependence and their associations with carbohydrate-deficient transferrin (CDT), a biomarker of chronic alcohol consumption, were evaluated in 21 patients with alcohol dependence and age- and sex-matched 21 healthy comparison subjects. Between-group difference in caudate volumes and correlations between CDT and caudate volumes in the patient group were examined after adjusting for age, sex, and intracranial volume. Volumetric analysis results show prominent abnormalities in the left caudate among patients with alcohol dependence (z = − 2.70, p = 0.007). CDT levels significantly predicted volumetric deficits in the left caudate (β = − 1.23, p = 0.003). These findings suggest that the caudate nucleus may be one of the important brain regions related to alcohol-induced chronic brain damages.

Original language	English
Pages (from-to)	946-955
Number of pages	10
Journal	International Journal of Mental Health and Addiction
Volume	16
Issue number	4
DOIs	https://doi.org/10.1007/s11469-017-9803-6
State	Published - 1 Aug 2018

Bibliographical note

Publisher Copyright:
© 2017, Springer Science+Business Media, LLC.

Keywords

Alcohol dependence
Brain volume
Carbohydrate-deficient transferrin
Caudate nucleus
Semi-automated segmentation
Structural magnetic resonance imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11469-017-9803-6

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Park, S., Jung, J. J., Kang, I., Lee, B. C., Lee, S. L., Ma, J., Kim, J., Cho, H. B., Jeong, H. S., Lim, S. M., Hong, Y. S., Choi, I. G., & Kim, J. E. (2018). Caudate Volumetric Reductions Predicted by Carbohydrate-Deficient Transferrin in Patients with Alcohol Dependence. International Journal of Mental Health and Addiction, 16(4), 946-955. https://doi.org/10.1007/s11469-017-9803-6

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title = "Caudate Volumetric Reductions Predicted by Carbohydrate-Deficient Transferrin in Patients with Alcohol Dependence",

abstract = "The caudate nucleus has shown a high relevance with substance craving and addiction in the pathophysiology of alcohol dependence. In this study, caudate volumetric deficits in patients with alcohol dependence and their associations with carbohydrate-deficient transferrin (CDT), a biomarker of chronic alcohol consumption, were evaluated in 21 patients with alcohol dependence and age- and sex-matched 21 healthy comparison subjects. Between-group difference in caudate volumes and correlations between CDT and caudate volumes in the patient group were examined after adjusting for age, sex, and intracranial volume. Volumetric analysis results show prominent abnormalities in the left caudate among patients with alcohol dependence (z = − 2.70, p = 0.007). CDT levels significantly predicted volumetric deficits in the left caudate (β = − 1.23, p = 0.003). These findings suggest that the caudate nucleus may be one of the important brain regions related to alcohol-induced chronic brain damages.",

keywords = "Alcohol dependence, Brain volume, Carbohydrate-deficient transferrin, Caudate nucleus, Semi-automated segmentation, Structural magnetic resonance imaging",

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doi = "10.1007/s11469-017-9803-6",

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AU - Lee, Suji L.

AU - Ma, Jiyoung

AU - Kim, Jungyoon

AU - Cho, Han Byul

AU - Jeong, Hyeonseok S.

AU - Lim, Soo Mee

AU - Hong, Young Sun

AU - Choi, Ihn Geun

AU - Kim, Jieun E.

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N2 - The caudate nucleus has shown a high relevance with substance craving and addiction in the pathophysiology of alcohol dependence. In this study, caudate volumetric deficits in patients with alcohol dependence and their associations with carbohydrate-deficient transferrin (CDT), a biomarker of chronic alcohol consumption, were evaluated in 21 patients with alcohol dependence and age- and sex-matched 21 healthy comparison subjects. Between-group difference in caudate volumes and correlations between CDT and caudate volumes in the patient group were examined after adjusting for age, sex, and intracranial volume. Volumetric analysis results show prominent abnormalities in the left caudate among patients with alcohol dependence (z = − 2.70, p = 0.007). CDT levels significantly predicted volumetric deficits in the left caudate (β = − 1.23, p = 0.003). These findings suggest that the caudate nucleus may be one of the important brain regions related to alcohol-induced chronic brain damages.

AB - The caudate nucleus has shown a high relevance with substance craving and addiction in the pathophysiology of alcohol dependence. In this study, caudate volumetric deficits in patients with alcohol dependence and their associations with carbohydrate-deficient transferrin (CDT), a biomarker of chronic alcohol consumption, were evaluated in 21 patients with alcohol dependence and age- and sex-matched 21 healthy comparison subjects. Between-group difference in caudate volumes and correlations between CDT and caudate volumes in the patient group were examined after adjusting for age, sex, and intracranial volume. Volumetric analysis results show prominent abnormalities in the left caudate among patients with alcohol dependence (z = − 2.70, p = 0.007). CDT levels significantly predicted volumetric deficits in the left caudate (β = − 1.23, p = 0.003). These findings suggest that the caudate nucleus may be one of the important brain regions related to alcohol-induced chronic brain damages.

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Caudate Volumetric Reductions Predicted by Carbohydrate-Deficient Transferrin in Patients with Alcohol Dependence

Abstract

Bibliographical note

Keywords

UN SDGs

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