Catechol-grafted poly(ethylene glycol) for PEGylation on versatile substrates

Hyukjin Lee, Kang Dae Lee, Kyung Bo Pyo, Sung Young Park, Haeshin Lee

Research output: Contribution to journalArticlepeer-review

138 Scopus citations


We report on catechol-grafted poly(ethylene) glycol (PEG-g-catechol) for the preparation of nonfouling surfaces on versatile substrates including adhesion-resistant PTFE. PEG-g-catechol was prepared by the step-growth polymerization of PEO to which dopamine, a mussel-derived adhesive molecule, was conjugated. The immersion of substrates into an aqueous solution of PEG-g-catechol resulted in robust PEGylation on versatile surfaces of noble metals, oxides, and synthetic polymers. Surface PEGylation was unambiguously confirmed by various surface analytical tools such as ellipsometry, goniometry, infrared spectroscopy, and X-ray photoelectron spectroscopy. Contrary to existing PEG derivatives that are difficult-to-modify synthetic polymer surfaces, PEG-g-catechol can be considered to be a new class of PEGs for the facile surface PEGylation of various types of surfaces.

Original languageEnglish
Pages (from-to)3790-3793
Number of pages4
Issue number6
StatePublished - 16 Mar 2010


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