Catechol-Amyloid Interactions

Nghia T.K. Le, Eun Joo Kang, Ji Hun Park, Kyungtae Kang

Research output: Contribution to journalReview articlepeer-review


This review introduces multifaceted mutual interactions between molecules containing a catechol moiety and aggregation-prone proteins. The complex relationships between these two molecular species have previously been elucidated primarily in a unidirectional manner, as demonstrated in cases involving the development of catechol-based inhibitors for amyloid aggregation and the elucidation of the role of functional amyloid fibers in melanin biosynthesis. This review aims to consolidate scattered clues pertaining to catechol-based amyloid inhibitors, functional amyloid scaffold of melanin biosynthesis, and chemically designed peptide fibers for providing chemical insights into the role of the local three-dimensional orientation of functional groups in manifesting such interactions. These orientations may play crucial, yet undiscovered, roles in various supramolecular structures.

Original languageEnglish
Article numbere202300628
Issue number24
StatePublished - 14 Dec 2023

Bibliographical note

Publisher Copyright:
© 2023 Wiley-VCH GmbH.


  • amyloid
  • catechol
  • melanin
  • peptide assembly
  • polyphenolic compounds


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