Catechins activate muscle stem cells by Myf5 induction and stimulate muscle regeneration

A. Rum Kim, Kyung Min Kim, Mi Ran Byun, Jun Ha Hwang, Jung Il Park, Ho Taek Oh, Hyo Kyeong Kim, Mi Gyeong Jeong, Eun Sook Hwang, Jeong Ho Hong

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Muscle weakness is one of the most common symptoms in aged individuals and increases risk of mortality. Thus, maintenance of muscle mass is important for inhibiting aging. In this study, we investigated the effect of catechins, polyphenol compounds in green tea, on muscle regeneration. We found that (−)-epicatechin gallate (ECG) and (−)-epigallocatechin-3-gallate (EGCG) activate satellite cells by induction of Myf5 transcription factors. For satellite cell activation, Akt kinase was significantly induced after ECG treatment and ECG-induced satellite cell activation was blocked in the presence of Akt inhibitor. ECG also promotes myogenic differentiation through the induction of myogenic markers, including Myogenin and Muscle creatine kinase (MCK), in satellite and C2C12 myoblast cells. Finally, EGCG administration to mice significantly increased muscle fiber size for regeneration. Taken together, the results suggest that catechins stimulate muscle stem cell activation and differentiation for muscle regeneration.

Original languageEnglish
Pages (from-to)142-148
Number of pages7
JournalBiochemical and Biophysical Research Communications
Issue number2
StatePublished - 22 Jul 2017

Bibliographical note

Funding Information:
This work was supported by the Basic Science Research Program through the National Research Foundation (NRF) of Korea funded by the Ministry of Education (2014R1A2A2A01006547 and 2015R1A5A1009024), Republic of Korea. This work was also supported by a Korea University grant.

Publisher Copyright:
© 2017 Elsevier Inc.


  • Catechins
  • Muscle regeneration
  • Myogenic differentiation
  • Phosphoinositide 3-kinases/Akt
  • Satellite cells


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