@article{0eb7c75623ec4d4aa05110283a4452e0,
title = "Catalytic recycling of NAD(P)H",
abstract = "A large number of industrially relevant enzymes depend upon dihydronicotinamide adenine dinucleotide (NADH) and dihydronicotinamide adenine dinucleotide phosphate (NADPH) cofactors, which are too expensive to be added in stoichiometric amounts. Existing NAD(P)H-recycling systems suffer from low activity, or the generation of side products. This review focuses on NAD(P)H cofactor regeneration catalyzed by transition metal complexes such as rhodium, ruthenium and iridium complexes using cheap reducing agents such as hydrogen (H2) and ethanol, which have attracted increasing attention as sustainable energy carriers. The catalytic mechanisms for the regioselective reduction of NAD(P)+ are discussed with emphasis on identification of catalytically active intermediates such as transition metal hydride complexes. Applications of NAD(P)H-recycling systems to develop artificial photosynthesis are also discussed.",
keywords = "Electron transfer, Metal hydride complexes, NAD(P), NAD(P)H, Redox catalysis",
author = "Shunichi Fukuzumi and Lee, {Yong Min} and Wonwoo Nam",
note = "Funding Information: The authors gratefully acknowledge the contributions of their collaborators and coworkers mentioned in the cited references, and financial supports by a SENTAN project from JST and JSPS KAKENHI (Grant Numbers 16H02268 to S.F.) from MEXT , Japan and by the NRF of Korea through CRI ( NRF-2012R1A3A2048842 to W.N.), GRL ( NRF-2010-00353 to W.N.), and Basic Science Research Program ( 2017R1D1A1B03029982 to Y.-M.L. and 2017R1D1A1B03032615 to S.F.). Funding Information: The authors gratefully acknowledge the contributions of their collaborators and coworkers mentioned in the cited references, and financial supports by a SENTAN project from JST and JSPS KAKENHI (Grant Numbers 16H02268 to S.F.) from MEXT, Japan and by the NRF of Korea through CRI (NRF-2012R1A3A2048842 to W.N.), GRL (NRF-2010-00353 to W.N.), and Basic Science Research Program (2017R1D1A1B03029982 to Y.-M.L. and 2017R1D1A1B03032615 to S.F.). Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
month = oct,
doi = "10.1016/j.jinorgbio.2019.110777",
language = "English",
volume = "199",
journal = "Journal of Inorganic Biochemistry",
issn = "0162-0134",
publisher = "Elsevier Inc.",
}