Catalytic recycling of NAD(P)H

Shunichi Fukuzumi, Yong Min Lee, Wonwoo Nam

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

A large number of industrially relevant enzymes depend upon dihydronicotinamide adenine dinucleotide (NADH) and dihydronicotinamide adenine dinucleotide phosphate (NADPH) cofactors, which are too expensive to be added in stoichiometric amounts. Existing NAD(P)H-recycling systems suffer from low activity, or the generation of side products. This review focuses on NAD(P)H cofactor regeneration catalyzed by transition metal complexes such as rhodium, ruthenium and iridium complexes using cheap reducing agents such as hydrogen (H2) and ethanol, which have attracted increasing attention as sustainable energy carriers. The catalytic mechanisms for the regioselective reduction of NAD(P)+ are discussed with emphasis on identification of catalytically active intermediates such as transition metal hydride complexes. Applications of NAD(P)H-recycling systems to develop artificial photosynthesis are also discussed.

Original languageEnglish
Article number110777
JournalJournal of Inorganic Biochemistry
Volume199
DOIs
StatePublished - Oct 2019

Keywords

  • Electron transfer
  • Metal hydride complexes
  • NAD(P)
  • NAD(P)H
  • Redox catalysis

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