Carotid intima-media thickness in Parkinson's disease

Jong Moon Lee; Kun Woo Park; Woo Keun Seo; Ho Park Moon; Changsu Han; Inho Jo; Ahn Jo Sangmee

doi:10.1002/mds.21757

Carotid intima-media thickness in Parkinson's disease

Jong Moon Lee, Kun Woo Park, Woo Keun Seo, Ho Park Moon, Changsu Han, Inho Jo, Ahn Jo Sangmee

Department of Molecular Medicine

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

There have been a few studies and inconsistent results regarding the coincidence of Parkinson's disease (PD) and atherosclerotic diseases, such as cerebrovascular disease. Carotid intima-media thickness (IMT) is a known marker for subclinical atherosclerosis. The aim of this study was to investigate the carotid IMT between PD patients and controls. We studied 43 patients with PD and 86 matched controls. The carotid IMT in PD patients was significantly smaller than in controls (0.796 ± 0.179 mm vs. 0.913 ± 0.237 mm, P < 0.05). In multivariate analysis, the carotid IMT was inversely associated with the duration of levodopa medication and the severity of PD. These results suggest that PD patients have a lower risk of atherosclerosis.

Original language	English
Pages (from-to)	2446-2449
Number of pages	4
Journal	Movement Disorders
Volume	22
Issue number	16
DOIs	https://doi.org/10.1002/mds.21757
State	Published - Dec 2007

Keywords

Atherosclerosis
Intima-media thickness
Parkinson's disease

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title = "Carotid intima-media thickness in Parkinson's disease",

abstract = "There have been a few studies and inconsistent results regarding the coincidence of Parkinson's disease (PD) and atherosclerotic diseases, such as cerebrovascular disease. Carotid intima-media thickness (IMT) is a known marker for subclinical atherosclerosis. The aim of this study was to investigate the carotid IMT between PD patients and controls. We studied 43 patients with PD and 86 matched controls. The carotid IMT in PD patients was significantly smaller than in controls (0.796 ± 0.179 mm vs. 0.913 ± 0.237 mm, P < 0.05). In multivariate analysis, the carotid IMT was inversely associated with the duration of levodopa medication and the severity of PD. These results suggest that PD patients have a lower risk of atherosclerosis.",

keywords = "Atherosclerosis, Intima-media thickness, Parkinson's disease",

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AU - Lee, Jong Moon

AU - Park, Kun Woo

AU - Seo, Woo Keun

AU - Moon, Ho Park

AU - Han, Changsu

AU - Jo, Inho

AU - Sangmee, Ahn Jo

PY - 2007/12

Y1 - 2007/12

N2 - There have been a few studies and inconsistent results regarding the coincidence of Parkinson's disease (PD) and atherosclerotic diseases, such as cerebrovascular disease. Carotid intima-media thickness (IMT) is a known marker for subclinical atherosclerosis. The aim of this study was to investigate the carotid IMT between PD patients and controls. We studied 43 patients with PD and 86 matched controls. The carotid IMT in PD patients was significantly smaller than in controls (0.796 ± 0.179 mm vs. 0.913 ± 0.237 mm, P < 0.05). In multivariate analysis, the carotid IMT was inversely associated with the duration of levodopa medication and the severity of PD. These results suggest that PD patients have a lower risk of atherosclerosis.

AB - There have been a few studies and inconsistent results regarding the coincidence of Parkinson's disease (PD) and atherosclerotic diseases, such as cerebrovascular disease. Carotid intima-media thickness (IMT) is a known marker for subclinical atherosclerosis. The aim of this study was to investigate the carotid IMT between PD patients and controls. We studied 43 patients with PD and 86 matched controls. The carotid IMT in PD patients was significantly smaller than in controls (0.796 ± 0.179 mm vs. 0.913 ± 0.237 mm, P < 0.05). In multivariate analysis, the carotid IMT was inversely associated with the duration of levodopa medication and the severity of PD. These results suggest that PD patients have a lower risk of atherosclerosis.

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Carotid intima-media thickness in Parkinson's disease

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Keywords

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