TY - GEN
T1 - Carbon fiber based microeletrode with biodegradable silk for in vivo neural recording
AU - Lee, Yena
AU - Jun, Sang Beom
N1 - Funding Information:
ACKNOWLEDGMENT This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2019R1A6A3A01096763, NRF-2017R1A2B4006604) & the smart IT convergence system research center funded by the ministry of education, science and technology as global frontier project(CISS-2012M3A6A6054204).
Publisher Copyright:
© 2020 IEEE.
PY - 2020/1
Y1 - 2020/1
N2 - Microelectrode arrays are commonly used for electrophysiological neural recording from individual neurons in the brain to study neural pathway or to form an interface between brain and machine. However, it is also known that the electrode implantation into the brain often induces immunological tissue response around the electrode array, limiting the long-term neural recording. Since the diameter of carbon fiber can be much smaller than that of conventional microwires, carbon fiber based electrodes can reduce the response of glial response. In the present study, we proposed a carbon fiber based microelectrode array embedded with mechanical support structure to facilitate penetration into the deeper brain. The support is made of biodegradable silk fibroin to reduce the reactive responses. 4 channel carbon fiber based microelectrode arrays were fabricated and evaluated for electrochemical impedance, long term neural recording capability and immunohistochemical analysis for 1 month implantation in the rat brains.
AB - Microelectrode arrays are commonly used for electrophysiological neural recording from individual neurons in the brain to study neural pathway or to form an interface between brain and machine. However, it is also known that the electrode implantation into the brain often induces immunological tissue response around the electrode array, limiting the long-term neural recording. Since the diameter of carbon fiber can be much smaller than that of conventional microwires, carbon fiber based electrodes can reduce the response of glial response. In the present study, we proposed a carbon fiber based microelectrode array embedded with mechanical support structure to facilitate penetration into the deeper brain. The support is made of biodegradable silk fibroin to reduce the reactive responses. 4 channel carbon fiber based microelectrode arrays were fabricated and evaluated for electrochemical impedance, long term neural recording capability and immunohistochemical analysis for 1 month implantation in the rat brains.
KW - Carbon fiber
KW - Glial response
KW - Microelectrode
KW - Neural signal
UR - http://www.scopus.com/inward/record.url?scp=85083515436&partnerID=8YFLogxK
U2 - 10.1109/ICEIC49074.2020.9051026
DO - 10.1109/ICEIC49074.2020.9051026
M3 - Conference contribution
AN - SCOPUS:85083515436
T3 - 2020 International Conference on Electronics, Information, and Communication, ICEIC 2020
BT - 2020 International Conference on Electronics, Information, and Communication, ICEIC 2020
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2020 International Conference on Electronics, Information, and Communication, ICEIC 2020
Y2 - 19 January 2020 through 22 January 2020
ER -