Cannabidiol, a Regulator of Intracellular Calcium and Calpain

Kyung Hwa Jeon; Sang Hyuck Park; Woong Jin Bae; Sae Woong Kim; Hyo Jung Park; Soomin Kim; Tae Hyung Kim; Seung Hwan Jeon; Ilbum Park; Hyun Je Park; Youngjoo Kwon

doi:10.1089/can.2021.0197

Cannabidiol, a Regulator of Intracellular Calcium and Calpain

Kyung Hwa Jeon, Sang Hyuck Park, Woong Jin Bae, Sae Woong Kim, Hyo Jung Park, Soomin Kim, Tae Hyung Kim, Seung Hwan Jeon, Ilbum Park, Hyun Je Park, Youngjoo Kwon

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Cannabidiol (CBD) is one of the most abundant components of Cannabis and has long been used in Cannabis-based preparations. Recently, CBD has become a promising pharmacological agent because of its beneficial properties in the pathophysiology of several diseases. Although CBD is a kind of cannabinoid and acts on cannabinoid receptors (CB1 and CB2), molecular targets involved in diverse therapeutic properties of CBD have not been identified because CBD also interacts with other molecular targets. Considering that CBD alters the intracellular calcium level by which calpain activity is controlled, and both CBD and calpain are associated with various diseases related to calcium signaling, including neurological disorders, this review provides an overview of calpain and calcium signaling as possible molecular targets of CBD. As calpain is known to play an important role in the pathophysiology of neurological disease, a deeper understanding of its relationship with CBD will be meaningful. To understand the role of CBD as a calpain regulator, in silico structural analysis on the binding mode of CBD with calpain was performed.

Original language	English
Pages (from-to)	119-125
Number of pages	7
Journal	Cannabis and Cannabinoid Research
Volume	8
Issue number	1
DOIs	https://doi.org/10.1089/can.2021.0197
State	Published - 1 Feb 2023

Bibliographical note

Funding Information:
This study was supported by grants from National Research Foundation of Korea (NRF) grants funded by the Korean government (MSIT) (2019R1I1A1A01050921 and 2020R1A4A4079494) and by Korea Basic Science Institute (National Research Facilities and Equipment Center) grant funded by the Ministry of Education (2021R1A6C101A442)

Publisher Copyright:
© Copyright 2023, Mary Ann Liebert, Inc., publishers 2023.

Keywords

CBD
calpain
cannabidiol
intracellular calcium

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10.1089/can.2021.0197

Cite this

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title = "Cannabidiol, a Regulator of Intracellular Calcium and Calpain",

abstract = "Cannabidiol (CBD) is one of the most abundant components of Cannabis and has long been used in Cannabis-based preparations. Recently, CBD has become a promising pharmacological agent because of its beneficial properties in the pathophysiology of several diseases. Although CBD is a kind of cannabinoid and acts on cannabinoid receptors (CB1 and CB2), molecular targets involved in diverse therapeutic properties of CBD have not been identified because CBD also interacts with other molecular targets. Considering that CBD alters the intracellular calcium level by which calpain activity is controlled, and both CBD and calpain are associated with various diseases related to calcium signaling, including neurological disorders, this review provides an overview of calpain and calcium signaling as possible molecular targets of CBD. As calpain is known to play an important role in the pathophysiology of neurological disease, a deeper understanding of its relationship with CBD will be meaningful. To understand the role of CBD as a calpain regulator, in silico structural analysis on the binding mode of CBD with calpain was performed.",

keywords = "CBD, calpain, cannabidiol, intracellular calcium",

author = "Jeon, {Kyung Hwa} and Park, {Sang Hyuck} and Bae, {Woong Jin} and Kim, {Sae Woong} and Park, {Hyo Jung} and Soomin Kim and Kim, {Tae Hyung} and Jeon, {Seung Hwan} and Ilbum Park and Park, {Hyun Je} and Youngjoo Kwon",

note = "Funding Information: This study was supported by grants from National Research Foundation of Korea (NRF) grants funded by the Korean government (MSIT) (2019R1I1A1A01050921 and 2020R1A4A4079494) and by Korea Basic Science Institute (National Research Facilities and Equipment Center) grant funded by the Ministry of Education (2021R1A6C101A442) Publisher Copyright: {\textcopyright} Copyright 2023, Mary Ann Liebert, Inc., publishers 2023.",

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AU - Kim, Soomin

AU - Kim, Tae Hyung

AU - Jeon, Seung Hwan

AU - Park, Ilbum

AU - Park, Hyun Je

AU - Kwon, Youngjoo

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PY - 2023/2/1

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N2 - Cannabidiol (CBD) is one of the most abundant components of Cannabis and has long been used in Cannabis-based preparations. Recently, CBD has become a promising pharmacological agent because of its beneficial properties in the pathophysiology of several diseases. Although CBD is a kind of cannabinoid and acts on cannabinoid receptors (CB1 and CB2), molecular targets involved in diverse therapeutic properties of CBD have not been identified because CBD also interacts with other molecular targets. Considering that CBD alters the intracellular calcium level by which calpain activity is controlled, and both CBD and calpain are associated with various diseases related to calcium signaling, including neurological disorders, this review provides an overview of calpain and calcium signaling as possible molecular targets of CBD. As calpain is known to play an important role in the pathophysiology of neurological disease, a deeper understanding of its relationship with CBD will be meaningful. To understand the role of CBD as a calpain regulator, in silico structural analysis on the binding mode of CBD with calpain was performed.

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Cannabidiol, a Regulator of Intracellular Calcium and Calpain

Abstract

Bibliographical note

Keywords

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