Cannabidiol, a Regulator of Intracellular Calcium and Calpain

Kyung Hwa Jeon, Sang Hyuck Park, Woong Jin Bae, Sae Woong Kim, Hyo Jung Park, Soomin Kim, Tae Hyung Kim, Seung Hwan Jeon, Ilbum Park, Hyun Je Park, Youngjoo Kwon

Research output: Contribution to journalArticlepeer-review


Cannabidiol (CBD) is one of the most abundant components of Cannabis and has long been used in Cannabis-based preparations. Recently, CBD has become a promising pharmacological agent because of its beneficial properties in the pathophysiology of several diseases. Although CBD is a kind of cannabinoid and acts on cannabinoid receptors (CB1 and CB2), molecular targets involved in diverse therapeutic properties of CBD have not been identified because CBD also interacts with other molecular targets. Considering that CBD alters the intracellular calcium level by which calpain activity is controlled, and both CBD and calpain are associated with various diseases related to calcium signaling, including neurological disorders, this review provides an overview of calpain and calcium signaling as possible molecular targets of CBD. As calpain is known to play an important role in the pathophysiology of neurological disease, a deeper understanding of its relationship with CBD will be meaningful. To understand the role of CBD as a calpain regulator, in silico structural analysis on the binding mode of CBD with calpain was performed.

Original languageEnglish
Pages (from-to)119-125
Number of pages7
JournalCannabis and Cannabinoid Research
Issue number1
StatePublished - 1 Feb 2023


  • CBD
  • calpain
  • cannabidiol
  • intracellular calcium


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