Cadiolides J–M, antibacterial polyphenyl butenolides from the Korean tunicate Pseudodistoma antinboja

Weihong Wang; Hiyoung Kim; Rahul S. Patil; Awadut G. Giri; Dong Hwan Won; Dongyup Hahn; Youjung Sung; Jusung Lee; Hyukjae Choi; Sang Jip Nam; Heonjoong Kang

doi:10.1016/j.bmcl.2016.12.016

Cadiolides J–M, antibacterial polyphenyl butenolides from the Korean tunicate Pseudodistoma antinboja

Weihong Wang, Hiyoung Kim, Rahul S. Patil, Awadut G. Giri, Dong Hwan Won, Dongyup Hahn, Youjung Sung, Jusung Lee, Hyukjae Choi, Sang Jip Nam, Heonjoong Kang

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Activity-guided fractionations of the tunicate Pseudodistoma antinboja yielded four new compounds of the cadiolide class (cadiolides J–M, 1, 3–5) along with a known one (cadiolide H, 2). The structures were defined by spectroscopic methods including X-ray crystallographic analysis. These compounds were evaluated for their antibacterial activity and exhibited potent antibacterial activity against all of the drug resistant strains tested with MICs comparable to those of marketed drugs such as vancomycin and linezolid.

Original language	English
Pages (from-to)	574-577
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	27
Issue number	3
DOIs	https://doi.org/10.1016/j.bmcl.2016.12.016
State	Published - 2017

Bibliographical note

Funding Information:
The present study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science, ICT & Future Planning (NRF-2015M1A5A1037572 and NRF-2016M3A9B8914313).

Publisher Copyright:
© 2016 Elsevier Ltd

Keywords

Antibacterial activity
Pseudodistoma antinboja
Tunicate

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10.1016/j.bmcl.2016.12.016

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title = "Cadiolides J–M, antibacterial polyphenyl butenolides from the Korean tunicate Pseudodistoma antinboja",

abstract = "Activity-guided fractionations of the tunicate Pseudodistoma antinboja yielded four new compounds of the cadiolide class (cadiolides J–M, 1, 3–5) along with a known one (cadiolide H, 2). The structures were defined by spectroscopic methods including X-ray crystallographic analysis. These compounds were evaluated for their antibacterial activity and exhibited potent antibacterial activity against all of the drug resistant strains tested with MICs comparable to those of marketed drugs such as vancomycin and linezolid.",

keywords = "Antibacterial activity, Pseudodistoma antinboja, Tunicate",

author = "Weihong Wang and Hiyoung Kim and Patil, {Rahul S.} and Giri, {Awadut G.} and Won, {Dong Hwan} and Dongyup Hahn and Youjung Sung and Jusung Lee and Hyukjae Choi and Nam, {Sang Jip} and Heonjoong Kang",

note = "Funding Information: The present study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science, ICT & Future Planning (NRF-2015M1A5A1037572 and NRF-2016M3A9B8914313). Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd",

year = "2017",

doi = "10.1016/j.bmcl.2016.12.016",

language = "English",

volume = "27",

pages = "574--577",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

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T1 - Cadiolides J–M, antibacterial polyphenyl butenolides from the Korean tunicate Pseudodistoma antinboja

AU - Wang, Weihong

AU - Kim, Hiyoung

AU - Patil, Rahul S.

AU - Giri, Awadut G.

AU - Won, Dong Hwan

AU - Hahn, Dongyup

AU - Sung, Youjung

AU - Lee, Jusung

AU - Choi, Hyukjae

AU - Nam, Sang Jip

AU - Kang, Heonjoong

N1 - Funding Information: The present study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science, ICT & Future Planning (NRF-2015M1A5A1037572 and NRF-2016M3A9B8914313). Publisher Copyright: © 2016 Elsevier Ltd

PY - 2017

Y1 - 2017

N2 - Activity-guided fractionations of the tunicate Pseudodistoma antinboja yielded four new compounds of the cadiolide class (cadiolides J–M, 1, 3–5) along with a known one (cadiolide H, 2). The structures were defined by spectroscopic methods including X-ray crystallographic analysis. These compounds were evaluated for their antibacterial activity and exhibited potent antibacterial activity against all of the drug resistant strains tested with MICs comparable to those of marketed drugs such as vancomycin and linezolid.

AB - Activity-guided fractionations of the tunicate Pseudodistoma antinboja yielded four new compounds of the cadiolide class (cadiolides J–M, 1, 3–5) along with a known one (cadiolide H, 2). The structures were defined by spectroscopic methods including X-ray crystallographic analysis. These compounds were evaluated for their antibacterial activity and exhibited potent antibacterial activity against all of the drug resistant strains tested with MICs comparable to those of marketed drugs such as vancomycin and linezolid.

KW - Antibacterial activity

KW - Pseudodistoma antinboja

KW - Tunicate

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DO - 10.1016/j.bmcl.2016.12.016

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JO - Bioorganic and Medicinal Chemistry Letters

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IS - 3

ER -

Cadiolides J–M, antibacterial polyphenyl butenolides from the Korean tunicate Pseudodistoma antinboja

Abstract

Bibliographical note

Keywords

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