Cadiolides J–M, antibacterial polyphenyl butenolides from the Korean tunicate Pseudodistoma antinboja

Weihong Wang, Hiyoung Kim, Rahul S. Patil, Awadut G. Giri, Dong Hwan Won, Dongyup Hahn, Youjung Sung, Jusung Lee, Hyukjae Choi, Sang Jip Nam, Heonjoong Kang

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Activity-guided fractionations of the tunicate Pseudodistoma antinboja yielded four new compounds of the cadiolide class (cadiolides J–M, 1, 3–5) along with a known one (cadiolide H, 2). The structures were defined by spectroscopic methods including X-ray crystallographic analysis. These compounds were evaluated for their antibacterial activity and exhibited potent antibacterial activity against all of the drug resistant strains tested with MICs comparable to those of marketed drugs such as vancomycin and linezolid.

Original languageEnglish
Pages (from-to)574-577
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume27
Issue number3
DOIs
StatePublished - 2017

Keywords

  • Antibacterial activity
  • Pseudodistoma antinboja
  • Tunicate

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