Cadiolides J–M, antibacterial polyphenyl butenolides from the Korean tunicate Pseudodistoma antinboja

Weihong Wang, Hiyoung Kim, Rahul S. Patil, Awadut G. Giri, Dong Hwan Won, Dongyup Hahn, Youjung Sung, Jusung Lee, Hyukjae Choi, Sang Jip Nam, Heonjoong Kang

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Activity-guided fractionations of the tunicate Pseudodistoma antinboja yielded four new compounds of the cadiolide class (cadiolides J–M, 1, 3–5) along with a known one (cadiolide H, 2). The structures were defined by spectroscopic methods including X-ray crystallographic analysis. These compounds were evaluated for their antibacterial activity and exhibited potent antibacterial activity against all of the drug resistant strains tested with MICs comparable to those of marketed drugs such as vancomycin and linezolid.

Original languageEnglish
Pages (from-to)574-577
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number3
StatePublished - 2017

Bibliographical note

Funding Information:
The present study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science, ICT & Future Planning (NRF-2015M1A5A1037572 and NRF-2016M3A9B8914313).

Publisher Copyright:
© 2016 Elsevier Ltd


  • Antibacterial activity
  • Pseudodistoma antinboja
  • Tunicate


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