C1q/TNF-α-Related Protein 1 (CTRP1) maintains blood pressure under dehydration conditions

Sora Han, Ae Lee Jeong, Sunyi Lee, Jeong Su Park, Sumiyasuren Buyanravjikh, Wonku Kang, Seungmok Choi, Changmin Park, Jin Han, Woo Chan Son, Kyung Hyun Yoo, Jae Hoon Cheong, Goo Taeg Oh, Won Young Lee, Jongwan Kim, Suk Hyo Suh, Sang Hak Lee, Jong Seok Lim, Myeong Sok Lee, Young Yang

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Rationale: Circulating CTRP1 (C1q/TNF-α[tumor necrosis factor-α]-related protein 1) levels are increased in hypertensive patients compared with those in healthy subjects. Nonetheless, little is known about the molecular and physiological function of CTRP1 in blood pressure (BP) regulation. Objective: To investigate the physiological/pathophysiological role of CTRP1 in BP regulation. Methods and Results: CTRP1 production was increased to maintain normotension under dehydration conditions, and this function was impaired in inducible CTRP1 KO (knockout) mice (CTRP1ΔCAG). The increase in CTRP1 under dehydration conditions was mediated by glucocorticoids, and the antagonist mifepristone prevented the increase in CTRP1 and attenuated BP recovery. Treatment with a synthetic glucocorticoid increased the transcription, translation, and secretion of CTRP1 from skeletal muscle cells. Functionally, CTRP1 increases BP through the stimulation of the AT1R (Ang II [angiotensin II] receptor 1)-Rho (Ras homolog gene family)/ROCK (Rho kinase)-signaling pathway to induce vasoconstriction. CTRP1 promoted AT1R plasma membrane trafficking through phosphorylation of AKT and AKT substrate of 160 kDa (AS160). In addition, the administration of an AT1R blocker, losartan, recovered the hypertensive phenotype of CTRP1 TG (transgenic) mice. Conclusions: For the first time, we provide evidence that CTRP1 contributes to the regulation of BP homeostasis by preventing dehydration-induced hypotension.

Original languageEnglish
Pages (from-to)E5-E19
JournalCirculation Research
Issue number5
StatePublished - 2018

Bibliographical note

Publisher Copyright:
© 2018 American Heart Association, Inc.


  • Dehydration
  • Glucocorticoids
  • Hypertension
  • Mice
  • Vasoconstriction


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