Butler enables rapid cloud-based analysis of thousands of human genomes

PCAWG Technical Working Group, PCAWG Consortium

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


We present Butler, a computational tool that facilitates large-scale genomic analyses on public and academic clouds. Butler includes innovative anomaly detection and self-healing functions that improve the efficiency of data processing and analysis by 43% compared with current approaches. Butler enabled processing of a 725-terabyte cancer genome dataset from the Pan-Cancer Analysis of Whole Genomes (PCAWG) project in a time-efficient and uniform manner.

Original languageEnglish
Pages (from-to)288-292
Number of pages5
JournalNature Biotechnology
Issue number3
StatePublished - 1 Mar 2020

Bibliographical note

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© 2020, The Author(s).


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