@article{29bd41568b6f49f892d5db50340d9bbd,
title = "Butler enables rapid cloud-based analysis of thousands of human genomes",
abstract = "We present Butler, a computational tool that facilitates large-scale genomic analyses on public and academic clouds. Butler includes innovative anomaly detection and self-healing functions that improve the efficiency of data processing and analysis by 43% compared with current approaches. Butler enabled processing of a 725-terabyte cancer genome dataset from the Pan-Cancer Analysis of Whole Genomes (PCAWG) project in a time-efficient and uniform manner.",
author = "{PCAWG Technical Working Group} and {PCAWG Consortium} and Sergei Yakneen and Waszak, {Sebastian M.} and Sergei Yakneen and Brice Aminou and Javier Bartolome and Boroevich, {Keith A.} and Rich Boyce and Brooks, {Angela N.} and Alex Buchanan and Ivo Buchhalter and Butler, {Adam P.} and Byrne, {Niall J.} and Andy Cafferkey and Campbell, {Peter J.} and Zhaohong Chen and Sunghoon Cho and Wan Choi and Peter Clapham and Davis-Dusenbery, {Brandi N.} and {De La Vega}, {Francisco M.} and Jonas Demeulemeester and Dow, {Michelle T.} and Dursi, {Lewis Jonathan} and Juergen Eils and Roland Eils and Kyle Ellrott and Claudiu Farcas and Francesco Favero and Nodirjon Fayzullaev and Vincent Ferretti and Paul Flicek and Fonseca, {Nuno A.} and Gelpi, {Josep Ll} and Gad Getz and Bob Gibson and Grossman, {Robert L.} and Olivier Harismendy and Heath, {Allison P.} and Heinold, {Michael C.} and Hess, {Julian M.} and Oliver Hofmann and Hong, {Jongwhi H.} and Hudson, {Thomas J.} and Barbara Hutter and Hutter, {Carolyn M.} and Daniel H{\"u}bschmann and Seiya Imoto and Sinisa Ivkovic and Jeon, {Seung Hyup} and Kim, {Hyung Lae}",
note = "Funding Information: We acknowledge the contributions of the many clinical networks across ICGC and TCGA who provided samples and data to the PCAWG Consortium, and the contributions of the Technical Working Group and the Germline Working Group of the PCAWG Consortium for collation, realignment and harmonized variant calling of the PCAWG cancer genomes. We thank the patients and their families for their participation in the individual ICGC and TCGA projects. We also thank the PPCG project, and J. Weischenfeldt for assistance with the PPCG data. We are grateful to C. Yung, B. O{\textquoteright}Connor, J. Zhang and L. Stein for their assistance and invaluable advice throughout the project and to A. Cafferkey, C. Short, D. Oca{\~n}a, D. Vianello, E. van den Bergh, S. Newhouse and E. Birney for invaluable support with the EMBL-EBI Embassy Cloud used largely for the computing in this study. We also acknowledge The Cancer Genome Collaboratory, Amazon Web Services, Google Compute Platform and Microsoft Azure for providing computing or cloud infrastructure. J.O.K. acknowledges support by the EOSC Pilot study (European Commission award number 739563), the BMBF (de. NBI project 031A537B), the European Research Council (336045) and the Heidelberg Academy of Sciences and Humanities. S.W. was supported through an SNSF Early Postdoc Mobility fellowship (P2ELP3_155365) and an EMBO Long-Term Fellowship (ALTF 755-2014). Publisher Copyright: {\textcopyright} 2020, The Author(s).",
year = "2020",
month = mar,
day = "1",
doi = "10.1038/s41587-019-0360-3",
language = "English",
volume = "38",
pages = "288--292",
journal = "Nature Biotechnology",
issn = "1087-0156",
publisher = "Nature Publishing Group",
number = "3",
}