@article{29bd41568b6f49f892d5db50340d9bbd,
title = "Butler enables rapid cloud-based analysis of thousands of human genomes",
abstract = "We present Butler, a computational tool that facilitates large-scale genomic analyses on public and academic clouds. Butler includes innovative anomaly detection and self-healing functions that improve the efficiency of data processing and analysis by 43% compared with current approaches. Butler enabled processing of a 725-terabyte cancer genome dataset from the Pan-Cancer Analysis of Whole Genomes (PCAWG) project in a time-efficient and uniform manner.",
author = "{PCAWG Technical Working Group} and {PCAWG Consortium} and Sergei Yakneen and Waszak, {Sebastian M.} and Michael Gertz and Korbel, {Jan O.} and Brice Aminou and Javier Bartolome and Boroevich, {Keith A.} and Rich Boyce and Brooks, {Angela N.} and Alex Buchanan and Ivo Buchhalter and Butler, {Adam P.} and Byrne, {Niall J.} and Andy Cafferkey and Campbell, {Peter J.} and Zhaohong Chen and Sunghoon Cho and Wan Choi and Peter Clapham and Davis-Dusenbery, {Brandi N.} and {De La Vega}, {Francisco M.} and Jonas Demeulemeester and Dow, {Michelle T.} and Dursi, {Lewis Jonathan} and Juergen Eils and Roland Eils and Kyle Ellrott and Claudiu Farcas and Francesco Favero and Nodirjon Fayzullaev and Vincent Ferretti and Paul Flicek and Fonseca, {Nuno A.} and Gelpi, {Josep Ll} and Gad Getz and Bob Gibson and Grossman, {Robert L.} and Olivier Harismendy and Heath, {Allison P.} and Heinold, {Michael C.} and Hess, {Julian M.} and Oliver Hofmann and Hong, {Jongwhi H.} and Hudson, {Thomas J.} and Barbara Hutter and Hutter, {Carolyn M.} and Daniel H{\"u}bschmann and Seiya Imoto and Sinisa Ivkovic and Kim, {Hyung Lae}",
note = "Publisher Copyright: {\textcopyright} 2020, The Author(s).",
year = "2020",
month = mar,
day = "1",
doi = "10.1038/s41587-019-0360-3",
language = "English",
volume = "38",
pages = "288--292",
journal = "Nature Biotechnology",
issn = "1087-0156",
publisher = "Nature Research",
number = "3",
}