Breast Cancer after Radiation Therapy in a Patient with Li-Fraumeni Syndrome: A Case Report

In Na Yoon; Eun Suk Cha; Jeoung Hyun Kim; Jee Eun Lee; Jin Chung

doi:10.3348/jksr.2021.0045

Breast Cancer after Radiation Therapy in a Patient with Li-Fraumeni Syndrome: A Case Report

In Na Yoon, Eun Suk Cha, Jeoung Hyun Kim, Jee Eun Lee, Jin Chung

Department of Radiology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Li-Fraumeni syndrome (LFS) is an inherited autosomal-dominant tumor-predisposition disorder caused by germline mutations in the TP53 tumor suppressor gene. Since patients with LFS are likely to develop therapy-related cancers, radiation therapy should be avoided if breast cancer is found in these individuals. Herein, we present a case of secondary breast cancer in an LFS patient after radiation and chemotherapy for the first diagnosed breast sarcoma.

Original language	English
Pages (from-to)	246-251
Number of pages	6
Journal	Journal of the Korean Society of Radiology
Volume	83
Issue number	1
DOIs	https://doi.org/10.3348/jksr.2021.0045
State	Published - Jan 2022

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Publisher Copyright:
© 2022 Korean Radiological Society. All right reserved.

Keywords

Breast Neoplasms
Li-Fraumeni Syndrome
Sarcoma
Second Primary

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10.3348/jksr.2021.0045

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title = "Breast Cancer after Radiation Therapy in a Patient with Li-Fraumeni Syndrome: A Case Report",

abstract = "Li-Fraumeni syndrome (LFS) is an inherited autosomal-dominant tumor-predisposition disorder caused by germline mutations in the TP53 tumor suppressor gene. Since patients with LFS are likely to develop therapy-related cancers, radiation therapy should be avoided if breast cancer is found in these individuals. Herein, we present a case of secondary breast cancer in an LFS patient after radiation and chemotherapy for the first diagnosed breast sarcoma.",

keywords = "Breast Neoplasms, Li-Fraumeni Syndrome, Sarcoma, Second Primary",

author = "Yoon, {In Na} and Cha, {Eun Suk} and Kim, {Jeoung Hyun} and Lee, {Jee Eun} and Jin Chung",

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AU - Yoon, In Na

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AU - Kim, Jeoung Hyun

AU - Lee, Jee Eun

AU - Chung, Jin

PY - 2022/1

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N2 - Li-Fraumeni syndrome (LFS) is an inherited autosomal-dominant tumor-predisposition disorder caused by germline mutations in the TP53 tumor suppressor gene. Since patients with LFS are likely to develop therapy-related cancers, radiation therapy should be avoided if breast cancer is found in these individuals. Herein, we present a case of secondary breast cancer in an LFS patient after radiation and chemotherapy for the first diagnosed breast sarcoma.

AB - Li-Fraumeni syndrome (LFS) is an inherited autosomal-dominant tumor-predisposition disorder caused by germline mutations in the TP53 tumor suppressor gene. Since patients with LFS are likely to develop therapy-related cancers, radiation therapy should be avoided if breast cancer is found in these individuals. Herein, we present a case of secondary breast cancer in an LFS patient after radiation and chemotherapy for the first diagnosed breast sarcoma.

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KW - Li-Fraumeni Syndrome

KW - Sarcoma

KW - Second Primary

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IS - 1

ER -

Breast Cancer after Radiation Therapy in a Patient with Li-Fraumeni Syndrome: A Case Report

Abstract

Bibliographical note

Keywords

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