Brazilin inhibits UVB-induced MMP-1/3 expressions and secretions by suppressing the NF-κB pathway in human dermal fibroblasts

Young Rae Lee, Eun Mi Noh, Ji Hye Han, Jeong Mi Kim, Jin Ki Hwang, Bo Mi Hwang, Eun Yong Chung, Byeong Soo Kim, Sung Ho Lee, Seung Jin Lee, Jong Suk Kim

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Brazilin (7, 11b-dihydrobenz[b]indeno[1,2-d]pyran-3,6a,9,10 (6H)-tetrol), the major component of Caesalpinia sappan L., is a natural red pigment used for histological staining. Recent studies have shown that brazilin exhibits distinct biological effects, including anti-hepatotoxicity, antiplatelet activity, and anti-inflammatory activities. In the present study, we evaluated the effects of brazilin on MMP-1 and -3 expressions in human dermal fibroblasts exposed to ultraviolet B (UVB) irradiation. Brazilin showed protective effect on UVB-induced loss of cell viability of fibroblasts. Brazilin also blocked significantly UVB-induced Reactive Oxygen Species generation in fibroblasts. Brazilin inhibited UVB-induced MMP-1/3 expressions and secretions in a dose-dependent manner. Moreover, UVB-induced NF-κB activation was completely blocked by treatment with brazilin. These findings suggest that brazilin inhibits UVB-induced MMP-1/3 expressions and secretions by suppressing of NF-κB activation in human dermal fibroblasts. Thus, brazilin might be used as a potential agent for treatment of UV-induced skin photoaging.

Original languageEnglish
Pages (from-to)80-86
Number of pages7
JournalEuropean Journal of Pharmacology
Volume674
Issue number2-3
DOIs
StatePublished - 14 Jan 2012

Keywords

  • Brazilin
  • Matrix metalloproteinase
  • Nuclear factor-κB
  • Photoaging
  • Ultraviolet B

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