Boronate based fluorescence (ESIPT) probe for peroxynitrite

Adam C. Sedgwick, Xiaolong Sun, Gyoungmi Kim, Juyoung Yoon, Steven D. Bull, Tony D. James

Research output: Contribution to journalArticlepeer-review

107 Scopus citations

Abstract

A simple probe for the detection of peroxynitrite was developed incorporating a benzyl boronic ester "protecting" unit. The "protecting" unit of the probe is removed by peroxynitrite to "turn-on" ESIPT fluorescence (4.5 fold enhancement). Furthermore, the probe was cell permeable and was used in cell imaging experiments showing an off-on response towards peroxynitrite, in HeLa and RAW 264.7 cells.

Original languageEnglish
Pages (from-to)12350-12352
Number of pages3
JournalChemical Communications
Volume52
Issue number83
DOIs
StatePublished - 2016

Bibliographical note

Funding Information:
ACS, XS, SDB, and TDJ would like to thank the University of Bath for support. ACS thanks the EPSRC for a studentship. JY thanks the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (No. 2012R1A3A2048814). All data created during this research are openly available from the University of Bath data archive at http://doi.org/10.15125/BATH-00252.

Publisher Copyright:
© 2016 The Royal Society of Chemistry.

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