Boronate based fluorescence (ESIPT) probe for peroxynitrite

Adam C. Sedgwick, Xiaolong Sun, Gyoungmi Kim, Juyoung Yoon, Steven D. Bull, Tony D. James

Research output: Contribution to journalArticlepeer-review

88 Scopus citations

Abstract

A simple probe for the detection of peroxynitrite was developed incorporating a benzyl boronic ester "protecting" unit. The "protecting" unit of the probe is removed by peroxynitrite to "turn-on" ESIPT fluorescence (4.5 fold enhancement). Furthermore, the probe was cell permeable and was used in cell imaging experiments showing an off-on response towards peroxynitrite, in HeLa and RAW 264.7 cells.

Original languageEnglish
Pages (from-to)12350-12352
Number of pages3
JournalChemical Communications
Volume52
Issue number83
DOIs
StatePublished - 2016

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