Boronate based fluorescence (ESIPT) probe for peroxynitrite

Adam C. Sedgwick; Xiaolong Sun; Gyoungmi Kim; Juyoung Yoon; Steven D. Bull; Tony D. James

doi:10.1039/c6cc06829d

Boronate based fluorescence (ESIPT) probe for peroxynitrite

Adam C. Sedgwick, Xiaolong Sun, Gyoungmi Kim, Juyoung Yoon, Steven D. Bull, Tony D. James

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

112 Scopus citations

Abstract

A simple probe for the detection of peroxynitrite was developed incorporating a benzyl boronic ester "protecting" unit. The "protecting" unit of the probe is removed by peroxynitrite to "turn-on" ESIPT fluorescence (4.5 fold enhancement). Furthermore, the probe was cell permeable and was used in cell imaging experiments showing an off-on response towards peroxynitrite, in HeLa and RAW 264.7 cells.

Original language	English
Pages (from-to)	12350-12352
Number of pages	3
Journal	Chemical Communications
Volume	52
Issue number	83
DOIs	https://doi.org/10.1039/c6cc06829d
State	Published - 2016

Bibliographical note

Funding Information:
ACS, XS, SDB, and TDJ would like to thank the University of Bath for support. ACS thanks the EPSRC for a studentship. JY thanks the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (No. 2012R1A3A2048814). All data created during this research are openly available from the University of Bath data archive at http://doi.org/10.15125/BATH-00252.

Publisher Copyright:
© 2016 The Royal Society of Chemistry.

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abstract = "A simple probe for the detection of peroxynitrite was developed incorporating a benzyl boronic ester {"}protecting{"} unit. The {"}protecting{"} unit of the probe is removed by peroxynitrite to {"}turn-on{"} ESIPT fluorescence (4.5 fold enhancement). Furthermore, the probe was cell permeable and was used in cell imaging experiments showing an off-on response towards peroxynitrite, in HeLa and RAW 264.7 cells.",

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AU - Sedgwick, Adam C.

AU - Sun, Xiaolong

AU - Kim, Gyoungmi

AU - Yoon, Juyoung

AU - Bull, Steven D.

AU - James, Tony D.

N1 - Funding Information: ACS, XS, SDB, and TDJ would like to thank the University of Bath for support. ACS thanks the EPSRC for a studentship. JY thanks the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (No. 2012R1A3A2048814). All data created during this research are openly available from the University of Bath data archive at http://doi.org/10.15125/BATH-00252. Publisher Copyright: © 2016 The Royal Society of Chemistry.

PY - 2016

Y1 - 2016

N2 - A simple probe for the detection of peroxynitrite was developed incorporating a benzyl boronic ester "protecting" unit. The "protecting" unit of the probe is removed by peroxynitrite to "turn-on" ESIPT fluorescence (4.5 fold enhancement). Furthermore, the probe was cell permeable and was used in cell imaging experiments showing an off-on response towards peroxynitrite, in HeLa and RAW 264.7 cells.

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JF - Chemical Communications

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Boronate based fluorescence (ESIPT) probe for peroxynitrite

Abstract

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