Bone Graft Biomineral Complex Coderived from Marine Biocalcification and Biosilicification

Jinyoung Yun, Yeonsu Jeong, Onyou Nam, Ki Baek Yeo, Yun Kee Jo, Hye Ryoung Heo, Chang Sup Kim, Kye Il Joo, Seung Pil Pack, Eonseon Jin, Hyung Joon Cha

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Bone graft materials have been mainly developed based on inorganic materials, including calcium phosphate. However, these graft materials usually act as osteoconductive rather than osteoinductive scaffolds. To improve bone reconstruction, a combination of several materials has been proposed. However, there are still no alternatives that can completely replace the existing animal-derived bone graft materials. In this work, a marine-inspired biomineral complex was suggested as a potential bone graft material. The proposed biosilicified coccolithophore-derived coccoliths using bioengineered mussel adhesive proteins show osteopromotive ability through the synergistic effects of osteoconductivity from calcium carbonate and osteoinductivity from silica. Its possibility of use as a bone substitute was determined by evaluating the in vitro osteogenic behaviors of multipotent mesenchymal stem cells and in vivo bone regeneration in a rat calvarial defect model. Therefore, the marine-inspired biomineral complex developed in this study could be successfully used for bone tissue engineering.

Original languageEnglish
Pages (from-to)6046-6055
Number of pages10
JournalACS Applied Bio Materials
Issue number8
StatePublished - 16 Aug 2021

Bibliographical note

Funding Information:
Financial support was provided by the Basic Core Technology Development Program for the Oceans and the Polar Regions (NRF-2015M1A5A1037055) of the National Research Foundation funded by the Ministry of Science and ICT, Korea and the Marine Biomaterials Research Center grant (to H.J.C.) funded by the Ministry of Oceans and Fisheries, Korea. The authors also thank Nature Gluetech, Inc. for providing the bioengineered MAP and Pohang Center at Pohang Technopark for using μ-CT imaging equipment.

Publisher Copyright:
© 2021 American Chemical Society. All rights reserved.


  • biomineral
  • biosilica
  • bone regeneration
  • bone substitutes
  • coccoliths


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