BODIPY-functionalized gold nanoparticles as a selective fluoro-chromogenic chemosensor for imaging Cu2+ in living cells

Hye Young Lee; Hyunjong Son; Jung Mi Lim; Jungmin Oh; Dongmin Kang; Won Seok Han; Jong Hwa Jung

doi:10.1039/c0an00129e

BODIPY-functionalized gold nanoparticles as a selective fluoro-chromogenic chemosensor for imaging Cu²⁺ in living cells

Hye Young Lee, Hyunjong Son, Jung Mi Lim, Jungmin Oh, Dongmin Kang, Won Seok Han, Jong Hwa Jung

Department of Life Science

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

A new fluoro-chromogenic chemosensor based on BODIPY-functionalized gold nanoparticles 1 is prepared. Addition of Cu²⁺ ions to aqueous solutions of 1 gave an instantaneous color change along with a blue-shift of the absorption band and quenching of the emission spectrum at room temperature. The chemosensor 1 exhibits a high affinity and selectivity for Cu²⁺ over competing metal ions tested. Moreover, confocal microscopy experiments establish that 1 can be used for detecting Cu²⁺ levels within living cells.

Original language	English
Pages (from-to)	2022-2027
Number of pages	6
Journal	Analyst
Volume	135
Issue number	8
DOIs	https://doi.org/10.1039/c0an00129e
State	Published - Aug 2010

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abstract = "A new fluoro-chromogenic chemosensor based on BODIPY-functionalized gold nanoparticles 1 is prepared. Addition of Cu2+ ions to aqueous solutions of 1 gave an instantaneous color change along with a blue-shift of the absorption band and quenching of the emission spectrum at room temperature. The chemosensor 1 exhibits a high affinity and selectivity for Cu2+ over competing metal ions tested. Moreover, confocal microscopy experiments establish that 1 can be used for detecting Cu2+ levels within living cells.",

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AU - Oh, Jungmin

AU - Kang, Dongmin

AU - Han, Won Seok

AU - Jung, Jong Hwa

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AB - A new fluoro-chromogenic chemosensor based on BODIPY-functionalized gold nanoparticles 1 is prepared. Addition of Cu2+ ions to aqueous solutions of 1 gave an instantaneous color change along with a blue-shift of the absorption band and quenching of the emission spectrum at room temperature. The chemosensor 1 exhibits a high affinity and selectivity for Cu2+ over competing metal ions tested. Moreover, confocal microscopy experiments establish that 1 can be used for detecting Cu2+ levels within living cells.

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BODIPY-functionalized gold nanoparticles as a selective fluoro-chromogenic chemosensor for imaging Cu2+ in living cells

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BODIPY-functionalized gold nanoparticles as a selective fluoro-chromogenic chemosensor for imaging Cu²⁺ in living cells