Blood pressure lowering effect of korea ginseng derived ginseol K-g1

Moo Yong Rhee, Belong Cho, Kwang Il Kim, Joohee Kim, Mi Kyung Kim, Eun Kyung Lee, Hye Jin Kim, Cheol Ho Kim

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28 Scopus citations


We investigated the effect of Panax ginseng extract, which is rich in the ginsenoside protopanaxatriol (Ginseol K-g1), on blood pressure (BP). Adults over 20 years old with a systolic BP (SBP) between 120 and 159 mm Hg or a diastolic BP (DBP) between 80 and 99 mm Hg were included. At the end of an initial 2-week washout period, the patients were divided into three groups: the control group (placebo), the low-dose Ginseol K-g1 group (100 mg), and the high-dose Ginseol K-g1 (300 mg) group. The primary end point was the difference in seated SBP (seSBP) and seated DBP (seDBP) changes between the placebo and Ginseol K-g1 groups after 8 weeks of treatment. A total of 90 subjects participated in the study (mean age; 55.2 ± 11.8 years, 43 males). At week 8, levels of seSBP and seDBP were significantly decreased from baseline in the high-dose Ginseol K-g1 group (-3.1 mm Hg and -2.3 mm Hg, respectively, p < 0.05). In contrast, there was no significant decrease in seSBP or seDBP in the control or low-dose Ginseol K-g1 groups. No significant difference of seSBP and seDBP was identified among the three treatment groups at week 8. In patients who had a seSBP ≥ 130 mm Hg or an seDBP ≥ 85 mm Hg, the high dose of Ginseol K-g1 decreased the BP compared with the control group at week 4; however, there was no significant difference at week 8. The proportions of patients who experienced adverse events were comparable among the treatment groups. In conclusion, Ginseol K-g1 has a favorable effect on BP after 4 weeks of treatment, especially at a high dose. However, the effect is not maintained over 8 weeks. (Clinical trial registration information is available at , identifier: NCT01483430.)

Original languageEnglish
Pages (from-to)605-618
Number of pages14
JournalAmerican Journal of Chinese Medicine
Issue number3
StatePublished - 2014

Bibliographical note

Funding Information:
This work was supported by “Food Functionality Evaluation program” under the Ministry of Food, Agriculture, Forestry and Fisheries and was partially supported by the Korea Food Research Institute. This research was also supported by a grant from CJ Cheiljedang.


  • Blood Pressure
  • Clinical Trial
  • Ginseng
  • Ginseol K-g1


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