Blood pool activity on F-18 FDG PET/CT as a possible imaging biomarker of metabolic syndrome

Ji In Bang, Chang Mo Moon, Hye Ok Kim, Seo Young Kang, Hai Jeon Yoon, Bom Sahn Kim

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Association of blood pool (BP) and adipose tissue activity from F-18 fluorodeoxyglucose positron-emission tomography/computed tomography (FDG PET/CT) with the parameters of metabolic syndrome (MetS) and different MetS/obesity types were investigated. 245 subjects underwent FDG PET/CT scan for health check-ups were investigated retrospectively. Associations of BP (BP SUV: SUVmax, SUVmean), visceral (VAT SUV), and subcutaneous adipose tissue (SAT SUV) activity with parameters of MetS, body mass index (BMI), and lipid profiles were analyzed. MetS/obesity types were subdivided into metabolically healthy obese (MHO) and metabolically unhealthy obese (MUO). BP SUV was higher in subjects with MetS (t-test, P < 0.005), and was associated with MetS from multivariable binary logistic regression (OR 5.232 P = 0.010). BP SUV was statistically higher in MUO than in MHO (P < 0.05) along with blood pressure, triglycerides, and HDL-cholesterol. Multivariable binary logistic regression analysis showed MUO had higher blood pressure and BP SUV, while lower HDL-cholesterol relative to MHO after adjusting for triglycerides.

Original languageEnglish
Article number17367
JournalScientific Reports
Volume10
Issue number1
DOIs
StatePublished - 1 Dec 2020

Bibliographical note

Funding Information:
This study was funded by National Research Foundation of Korea (2018R1D1A1B07049400, 2018R1D1A1B07045321).

Publisher Copyright:
© 2020, The Author(s).

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