Blood amyloid-β oligomerization associated with neurodegeneration of Alzheimer's disease

Young Chul Youn, Sungmin Kang, Jeewon Suh, Young Ho Park, Min Ju Kang, Jung Min Pyun, Seong Hye Choi, Jee Hyang Jeong, Kyung Won Park, Ho Won Lee, Seong Soo A. An, Jacqueline C. Dominguez, Sangyun Kim

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Introduction: Oligomeric amyloid-ß is a major toxic species associated with Alzheimer's disease pathogenesis. Methods used to measure oligomeric amyloid-β in the blood have increased in number in recent years. The Multimer Detection System-Oligomeric Amyloid-β (MDS-OAβ) is a specific method to measure oligomerization tendencies in the blood. The objective of this study was to determine the association between amyloid-ß oligomerization in the plasma and structural changes of the brain. Methods: We studied 162 subjects composed of 92 community-based normal healthy subjects, 17 with subjective cognitive decline, 14 with mild cognitive impairment and 39 with Alzheimer's disease dementia. All subjects underwent MDS-OAβ and three-dimensional T1 magnetic resonance imaging. To determine the structural changes of the brain that are statistically correlated with MDS-OAβ level, we used voxel-based morphometry with corrections for age and total intracranial volume covariates. Results: We found brain volume reduction in the bilateral temporal, amygdala, parahippocampal and lower parietal lobe and left cingulate and precuneus regions (family-wise error, p < 0.05). Reduction was also found in white matter in proximity to the left temporal and bilateral lower parietal lobes and posterior corpus callosum (family-wise error, p < 0.05). Brain volume increment was not observed in any regions within grey or white matter. Discussion: Findings suggest that substantial correlation exists between amyloid ß oligomerization in the blood and brain volume reduction in the form of Alzheimer's disease despite of uncertainty in the casual relationship.

Original languageEnglish
Article number40
JournalAlzheimer's Research and Therapy
Volume11
Issue number1
DOIs
StatePublished - 10 May 2019

Bibliographical note

Funding Information:
This work was supported by a grant of the Korea Healthcare Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (HI14C1251).

Publisher Copyright:
© 2019 The Author(s).

Keywords

  • Amyloid β
  • Blood-based biomarker
  • Multimer detection system
  • Multimer detection system-oligomeric Aβ
  • Oligomer
  • Oligomerization
  • Voxel-based morphometry

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