Blockade by ginseng total saponin of methamphetamine-induced hyperactivity and conditioned place preference in mice

Hack Seang Kim; Choon Gon Jang; Woo Kyu Park; Ki Wan Oh; Hang Mock Rheu; Dae Hyun Cho; Seikwan Oh

doi:10.1016/0306-3623(95)02023-3

Blockade by ginseng total saponin of methamphetamine-induced hyperactivity and conditioned place preference in mice

Hack Seang Kim, Choon Gon Jang, Woo Kyu Park, Ki Wan Oh, Hang Mock Rheu, Dae Hyun Cho, Seikwan Oh

Department of Molecular Medicine

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Ginseng total saponin (GTS) inhibited methamphetamine-induced hyperactivity and conditioned place preference (CPP). Dopamine (DA) receptor supersensitivity was developed in methamphetamine-induced CPP mice and it was inhibited by GTS. GTS also inhibited apomorphine-induced climbing behavior, showing the antidopaminergic activity of GTS. These results suggest that GTS inhibition of the methamphetamine-induced hyperactivity and CPP may be closely related with the inhibition of dopaminergic activation induced by methamphetamine.

Original language	English
Pages (from-to)	199-204
Number of pages	6
Journal	General Pharmacology
Volume	27
Issue number	2
DOIs	https://doi.org/10.1016/0306-3623(95)02023-3
State	Published - Mar 1996

Keywords

conditioned place preference
dopamine receptor supersensitivity
hyperactivity
methamphetamine
panax ginseng

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10.1016/0306-3623(95)02023-3

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title = "Blockade by ginseng total saponin of methamphetamine-induced hyperactivity and conditioned place preference in mice",

abstract = "Ginseng total saponin (GTS) inhibited methamphetamine-induced hyperactivity and conditioned place preference (CPP). Dopamine (DA) receptor supersensitivity was developed in methamphetamine-induced CPP mice and it was inhibited by GTS. GTS also inhibited apomorphine-induced climbing behavior, showing the antidopaminergic activity of GTS. These results suggest that GTS inhibition of the methamphetamine-induced hyperactivity and CPP may be closely related with the inhibition of dopaminergic activation induced by methamphetamine.",

keywords = "conditioned place preference, dopamine receptor supersensitivity, hyperactivity, methamphetamine, panax ginseng",

author = "Kim, {Hack Seang} and Jang, {Choon Gon} and Park, {Woo Kyu} and Oh, {Ki Wan} and Rheu, {Hang Mock} and Cho, {Dae Hyun} and Seikwan Oh",

year = "1996",

month = mar,

doi = "10.1016/0306-3623(95)02023-3",

language = "English",

volume = "27",

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T1 - Blockade by ginseng total saponin of methamphetamine-induced hyperactivity and conditioned place preference in mice

AU - Kim, Hack Seang

AU - Jang, Choon Gon

AU - Park, Woo Kyu

AU - Oh, Ki Wan

AU - Rheu, Hang Mock

AU - Cho, Dae Hyun

AU - Oh, Seikwan

PY - 1996/3

Y1 - 1996/3

N2 - Ginseng total saponin (GTS) inhibited methamphetamine-induced hyperactivity and conditioned place preference (CPP). Dopamine (DA) receptor supersensitivity was developed in methamphetamine-induced CPP mice and it was inhibited by GTS. GTS also inhibited apomorphine-induced climbing behavior, showing the antidopaminergic activity of GTS. These results suggest that GTS inhibition of the methamphetamine-induced hyperactivity and CPP may be closely related with the inhibition of dopaminergic activation induced by methamphetamine.

AB - Ginseng total saponin (GTS) inhibited methamphetamine-induced hyperactivity and conditioned place preference (CPP). Dopamine (DA) receptor supersensitivity was developed in methamphetamine-induced CPP mice and it was inhibited by GTS. GTS also inhibited apomorphine-induced climbing behavior, showing the antidopaminergic activity of GTS. These results suggest that GTS inhibition of the methamphetamine-induced hyperactivity and CPP may be closely related with the inhibition of dopaminergic activation induced by methamphetamine.

KW - conditioned place preference

KW - dopamine receptor supersensitivity

KW - hyperactivity

KW - methamphetamine

KW - panax ginseng

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U2 - 10.1016/0306-3623(95)02023-3

DO - 10.1016/0306-3623(95)02023-3

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AN - SCOPUS:0029965849

SN - 0306-3623

VL - 27

SP - 199

EP - 204

JO - General Pharmacology

JF - General Pharmacology

IS - 2

ER -

Blockade by ginseng total saponin of methamphetamine-induced hyperactivity and conditioned place preference in mice

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Keywords

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