Bilirubin (BR), a bile pigment that exerts potent antioxidant and anti-inflammatory effects, is also a major constituent of black pigment gallstones found in bile ducts under certain pathological conditions. Inspired by the intrinsic metal-chelating power of BR found in gallstones, herein we report a cisplatin-chelated BR-based nanoparticle (cisPt@BRNP) for use as a new photonic nanomedicine for combined photoacoustic imaging and photothermal therapy of cancers. The cisPt@BRNPs were prepared by simply mixing cisplatin with BRNPs, yielding ca. 150-nm-size NPs. Upon near-IR laser irradiation at 808 nm, cisPt@BRNPs generated considerable heat and induced clear death of cancer cells in vitro. Following intravenous injection into human colon cancer-bearing mice, cisPt@BRNPs allowed effective tumor visualization by photoacoustic imaging and remarkable antitumor efficacy by photothermal therapy, suggesting their potential for use as a new photonic nanomedicine for cancer therapy.
Bibliographical noteFunding Information:
This work was supported by a grant from the Global Research Laboratory (NRF-2012K1A1A2045436) through the National Research Foundation of Korea (NRF), funded by the Ministry of Science, ICT & Future Planning.
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
- anticancer therapy
- bilirubin nanoparticles
- photoacoustic imaging
- photothermal therapy