TY - JOUR
T1 - Bisphenol A exposure is associated with oxidative stress and inflammation in postmenopausal women
AU - Yang, Yoon Jung
AU - Hong, Yun Chul
AU - Oh, Se Young
AU - Park, Min Seon
AU - Kim, Ho
AU - Leem, Jong Han
AU - Ha, Eun Hee
N1 - Funding Information:
The present study was supported by the Eco-technopia 21 project of Korea Institute of Environmental Science and Technology. This study was approved by the Institutional Review Boards of the Ewha Womans’ University Hospital and Inha University Hospital. Signed informed consent was obtained from all the participants.
PY - 2009/8
Y1 - 2009/8
N2 - Bisphenol A (BPA) is widely used in the production of polycarbonate plastics and epoxy resins. There is increasing health concerns regarding low-level exposure to BPA among the general population. The aim of this study was to determine the association between BPA exposure with oxidative stress and inflammation in adult populations. A cross-sectional study was conducted. This study included 485 adults (259 men, 92 premenopausal women, and 134 postmenopausal women) living in general communities within large cities. Urinary concentrations of BPA, malondialdehyde (MDA), and 8-hydroxydeoxyguanosine (8-OHdG), white blood cell (WBC) count, and C-reactive protein (CRP) were measured. Multivariate analyses were applied to determine the associations of BPA exposure with oxidative stress and inflammation. The geometric means of urinary BPA for men, premenopausal women, and postmenopausal women were 0.53, 0.61, and 0.58 μg/g cr, respectively. The urinary BPA concentrations were positively associated with MDA, 8-OHdG, and CRP levels in the postmenopausal women; however, such associations did not exist in men and premenopausal women. The findings of this study suggest that BPA exposure would promote oxidative stress and inflammation, in which postmenopausal women are likely to be more susceptible to BPA-induced health effects.
AB - Bisphenol A (BPA) is widely used in the production of polycarbonate plastics and epoxy resins. There is increasing health concerns regarding low-level exposure to BPA among the general population. The aim of this study was to determine the association between BPA exposure with oxidative stress and inflammation in adult populations. A cross-sectional study was conducted. This study included 485 adults (259 men, 92 premenopausal women, and 134 postmenopausal women) living in general communities within large cities. Urinary concentrations of BPA, malondialdehyde (MDA), and 8-hydroxydeoxyguanosine (8-OHdG), white blood cell (WBC) count, and C-reactive protein (CRP) were measured. Multivariate analyses were applied to determine the associations of BPA exposure with oxidative stress and inflammation. The geometric means of urinary BPA for men, premenopausal women, and postmenopausal women were 0.53, 0.61, and 0.58 μg/g cr, respectively. The urinary BPA concentrations were positively associated with MDA, 8-OHdG, and CRP levels in the postmenopausal women; however, such associations did not exist in men and premenopausal women. The findings of this study suggest that BPA exposure would promote oxidative stress and inflammation, in which postmenopausal women are likely to be more susceptible to BPA-induced health effects.
KW - Bisphenol A
KW - Cross-sectional studies
KW - Inflammation
KW - Oxidative stress
KW - Postmenopausal woman
UR - http://www.scopus.com/inward/record.url?scp=67649390763&partnerID=8YFLogxK
U2 - 10.1016/j.envres.2009.04.014
DO - 10.1016/j.envres.2009.04.014
M3 - Article
C2 - 19464675
AN - SCOPUS:67649390763
SN - 0013-9351
VL - 109
SP - 797
EP - 801
JO - Environmental Research
JF - Environmental Research
IS - 6
ER -