Bisphenol A exposure is associated with oxidative stress and inflammation in postmenopausal women

Yoon Jung Yang, Yun Chul Hong, Se Young Oh, Min Seon Park, Ho Kim, Jong Han Leem, Eun Hee Ha

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178 Scopus citations


Bisphenol A (BPA) is widely used in the production of polycarbonate plastics and epoxy resins. There is increasing health concerns regarding low-level exposure to BPA among the general population. The aim of this study was to determine the association between BPA exposure with oxidative stress and inflammation in adult populations. A cross-sectional study was conducted. This study included 485 adults (259 men, 92 premenopausal women, and 134 postmenopausal women) living in general communities within large cities. Urinary concentrations of BPA, malondialdehyde (MDA), and 8-hydroxydeoxyguanosine (8-OHdG), white blood cell (WBC) count, and C-reactive protein (CRP) were measured. Multivariate analyses were applied to determine the associations of BPA exposure with oxidative stress and inflammation. The geometric means of urinary BPA for men, premenopausal women, and postmenopausal women were 0.53, 0.61, and 0.58 μg/g cr, respectively. The urinary BPA concentrations were positively associated with MDA, 8-OHdG, and CRP levels in the postmenopausal women; however, such associations did not exist in men and premenopausal women. The findings of this study suggest that BPA exposure would promote oxidative stress and inflammation, in which postmenopausal women are likely to be more susceptible to BPA-induced health effects.

Original languageEnglish
Pages (from-to)797-801
Number of pages5
JournalEnvironmental Research
Issue number6
StatePublished - Aug 2009

Bibliographical note

Funding Information:
The present study was supported by the Eco-technopia 21 project of Korea Institute of Environmental Science and Technology. This study was approved by the Institutional Review Boards of the Ewha Womans’ University Hospital and Inha University Hospital. Signed informed consent was obtained from all the participants.


  • Bisphenol A
  • Cross-sectional studies
  • Inflammation
  • Oxidative stress
  • Postmenopausal woman


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