Bisbakuchiols A and B, novel dimeric meroterpenoids from Psoralea corylifolia

Cheng Zhu Wu; Xing Fu Cai; Nguyen Tien Dat; Seong Su Hong; Ah Reum Han; Eun Kyoung Seo; Bang Yeon Hwang; Ji Xing Nan; Dongho Lee; Jung Joon Lee

doi:10.1016/j.tetlet.2007.10.059

Bisbakuchiols A and B, novel dimeric meroterpenoids from Psoralea corylifolia

Cheng Zhu Wu, Xing Fu Cai, Nguyen Tien Dat, Seong Su Hong, Ah Reum Han, Eun Kyoung Seo, Bang Yeon Hwang, Ji Xing Nan, Dongho Lee, Jung Joon Lee

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Two novel dimeric meroterpenoids, bisbakuchiols A and B, along with (S)-bakuchiol were isolated from the seeds of Psoralea corylifolia L. (Fabaceae). Bisbakuchiols A and B contain an unprecedented dimeric meroterpenoid skeleton in which two meroterpenes are linked through a dioxane bridge. All compounds were evaluated for their potential to inhibit hypoxia-inducible factor-1 (HIF-1) activation induced by hypoxia in a HIF-1-mediated reporter gene assay in AGS human gastric cancer cells. (S)-Bakuchiol inhibited hypoxic activation of HIF-1 with an IC₅₀ value of 6.1 μM.

Original language	English
Pages (from-to)	8861-8864
Number of pages	4
Journal	Tetrahedron Letters
Volume	48
Issue number	50
DOIs	https://doi.org/10.1016/j.tetlet.2007.10.059
State	Published - 10 Dec 2007

Bibliographical note

Funding Information:
This work was supported by the Korea Research Foundation Grant funded by the Korean Government (MOEHRD, Basic Research Promotion Fund) (KRF-2006-311-E00588 to D. Lee) and by a Research Grant (PF06204-00 to J. J. Lee) from Plant Diversity Research Center of 21st Frontier Research Program funded by the Korean Ministry of Science and Technology. We thank the Korea Basic Science Institute for providing certain instruments used in this study.

Keywords

Fabaceae
Hypoxia-inducible factor-1
Meroterpenoid
Psoralea corylifolia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tetlet.2007.10.059

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title = "Bisbakuchiols A and B, novel dimeric meroterpenoids from Psoralea corylifolia",

abstract = "Two novel dimeric meroterpenoids, bisbakuchiols A and B, along with (S)-bakuchiol were isolated from the seeds of Psoralea corylifolia L. (Fabaceae). Bisbakuchiols A and B contain an unprecedented dimeric meroterpenoid skeleton in which two meroterpenes are linked through a dioxane bridge. All compounds were evaluated for their potential to inhibit hypoxia-inducible factor-1 (HIF-1) activation induced by hypoxia in a HIF-1-mediated reporter gene assay in AGS human gastric cancer cells. (S)-Bakuchiol inhibited hypoxic activation of HIF-1 with an IC50 value of 6.1 μM.",

keywords = "Fabaceae, Hypoxia-inducible factor-1, Meroterpenoid, Psoralea corylifolia",

author = "Wu, {Cheng Zhu} and Cai, {Xing Fu} and Dat, {Nguyen Tien} and Hong, {Seong Su} and Han, {Ah Reum} and Seo, {Eun Kyoung} and Hwang, {Bang Yeon} and Nan, {Ji Xing} and Dongho Lee and Lee, {Jung Joon}",

note = "Funding Information: This work was supported by the Korea Research Foundation Grant funded by the Korean Government (MOEHRD, Basic Research Promotion Fund) (KRF-2006-311-E00588 to D. Lee) and by a Research Grant (PF06204-00 to J. J. Lee) from Plant Diversity Research Center of 21st Frontier Research Program funded by the Korean Ministry of Science and Technology. We thank the Korea Basic Science Institute for providing certain instruments used in this study. ",

year = "2007",

month = dec,

day = "10",

doi = "10.1016/j.tetlet.2007.10.059",

language = "English",

volume = "48",

pages = "8861--8864",

journal = "Tetrahedron Letters",

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TY - JOUR

T1 - Bisbakuchiols A and B, novel dimeric meroterpenoids from Psoralea corylifolia

AU - Wu, Cheng Zhu

AU - Cai, Xing Fu

AU - Dat, Nguyen Tien

AU - Hong, Seong Su

AU - Han, Ah Reum

AU - Seo, Eun Kyoung

AU - Hwang, Bang Yeon

AU - Nan, Ji Xing

AU - Lee, Dongho

AU - Lee, Jung Joon

N1 - Funding Information: This work was supported by the Korea Research Foundation Grant funded by the Korean Government (MOEHRD, Basic Research Promotion Fund) (KRF-2006-311-E00588 to D. Lee) and by a Research Grant (PF06204-00 to J. J. Lee) from Plant Diversity Research Center of 21st Frontier Research Program funded by the Korean Ministry of Science and Technology. We thank the Korea Basic Science Institute for providing certain instruments used in this study.

PY - 2007/12/10

Y1 - 2007/12/10

N2 - Two novel dimeric meroterpenoids, bisbakuchiols A and B, along with (S)-bakuchiol were isolated from the seeds of Psoralea corylifolia L. (Fabaceae). Bisbakuchiols A and B contain an unprecedented dimeric meroterpenoid skeleton in which two meroterpenes are linked through a dioxane bridge. All compounds were evaluated for their potential to inhibit hypoxia-inducible factor-1 (HIF-1) activation induced by hypoxia in a HIF-1-mediated reporter gene assay in AGS human gastric cancer cells. (S)-Bakuchiol inhibited hypoxic activation of HIF-1 with an IC50 value of 6.1 μM.

AB - Two novel dimeric meroterpenoids, bisbakuchiols A and B, along with (S)-bakuchiol were isolated from the seeds of Psoralea corylifolia L. (Fabaceae). Bisbakuchiols A and B contain an unprecedented dimeric meroterpenoid skeleton in which two meroterpenes are linked through a dioxane bridge. All compounds were evaluated for their potential to inhibit hypoxia-inducible factor-1 (HIF-1) activation induced by hypoxia in a HIF-1-mediated reporter gene assay in AGS human gastric cancer cells. (S)-Bakuchiol inhibited hypoxic activation of HIF-1 with an IC50 value of 6.1 μM.

KW - Fabaceae

KW - Hypoxia-inducible factor-1

KW - Meroterpenoid

KW - Psoralea corylifolia

UR - http://www.scopus.com/inward/record.url?scp=36048977618&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2007.10.059

DO - 10.1016/j.tetlet.2007.10.059

M3 - Article

AN - SCOPUS:36048977618

SN - 0040-4039

VL - 48

SP - 8861

EP - 8864

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 50

ER -

Bisbakuchiols A and B, novel dimeric meroterpenoids from Psoralea corylifolia

Abstract

Bibliographical note

Keywords

UN SDGs

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