Biosynthetic pathways of aminoglycosides and their engineering

Je Won Park, Yeon Hee Ban, Sang Jip Nam, Sun Shin Cha, Yeo Joon Yoon

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Despite decades long clinical usage, aminoglycosides still remain a valuable pharmaceutical source for fighting Gram-negative bacterial pathogens, and their newly identified bioactivities are also renewing interest in this old class of antibiotics. As Nature's gift, some aminoglycosides possess natural defensive structural elements that can circumvent drug resistance mechanisms. Thus, a detailed understanding of aminoglycoside biosynthesis will enable us to apply Nature's biosynthetic strategy towards expanding structural diversity in order to produce novel and more robust aminoglycoside analogs. The engineered biosynthesis of novel aminoglycosides is required not only to develop effective therapeutics against the emerging ‘superbugs’ but also to reinvigorate antibiotic lead discovery in readiness for the emerging post-antibiotic era.

Original languageEnglish
Pages (from-to)33-41
Number of pages9
JournalCurrent Opinion in Biotechnology
StatePublished - 1 Dec 2017

Bibliographical note

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© 2017 Elsevier Ltd


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