Bioorthogonal copper-free click chemistry inVivo for tumor-targeted delivery of nanoparticles

Heebeom Koo; Sangmin Lee; Jin Hee Na; Sun Hwa Kim; Sei Kwang Hahn; Kuiwon Choi; Ick Chan Kwon; Seo Young Jeong; Kwangmeyung Kim

doi:10.1002/anie.201206703

Bioorthogonal copper-free click chemistry inVivo for tumor-targeted delivery of nanoparticles

Heebeom Koo, Sangmin Lee, Jin Hee Na, Sun Hwa Kim, Sei Kwang Hahn, Kuiwon Choi, Ick Chan Kwon, Seo Young Jeong, Kwangmeyung Kim

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

233 Scopus citations

Abstract

Right on target: An invivo tumor-targeting strategy using nanoparticles has been developed. An unnatural sialic acid (green, see scheme) with azide groups is artificially generated on the target site by metabolic glycoengineering. These groups then effectively enhance the accumulation of nanoparticles in the target tumor site by an invivo bioorthogonal copper-free click reaction.

Original language	English
Pages (from-to)	11836-11840
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	47
DOIs	https://doi.org/10.1002/anie.201206703
State	Published - 19 Nov 2012

Keywords

click chemistry
drug delivery
metabolic glycoengineering
nanoparticle
tumor targeting

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10.1002/anie.201206703

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abstract = "Right on target: An invivo tumor-targeting strategy using nanoparticles has been developed. An unnatural sialic acid (green, see scheme) with azide groups is artificially generated on the target site by metabolic glycoengineering. These groups then effectively enhance the accumulation of nanoparticles in the target tumor site by an invivo bioorthogonal copper-free click reaction.",

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AU - Hahn, Sei Kwang

AU - Choi, Kuiwon

AU - Kwon, Ick Chan

AU - Jeong, Seo Young

AU - Kim, Kwangmeyung

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KW - click chemistry

KW - drug delivery

KW - metabolic glycoengineering

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KW - tumor targeting

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Bioorthogonal copper-free click chemistry inVivo for tumor-targeted delivery of nanoparticles

Abstract

Keywords

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