Surface engineering is a key approach for tailoring new functionalities into biomaterials to achieve better clinical performance. The rise of genetic engineering and molecular biotechnology made it possible to design artificial sticky proteins derived from marine mussels that are capable of firmly anchoring on a variety of substrates with high binding strength, opening a new route for surface engineering of biomaterials. Coatings of recombinant mussel adhesive proteins (MAPs) have aroused great interest for the surface functionalization of biomaterials due to their simplicity, versatility, and high stability under physiological conditions, as well as their favorable interactions with cells. In addition, recombinant MAPs can be engineered to provide desired specific functionalities on target surfaces by genetic fusion with functional peptides and/or by the immobilization of biomolecules. This review provides an overview of recombinant MAPs-based surface coatings, highlighting their mechanisms, characteristic surface properties, and diverse applications in providing bioengineered surfaces in the fields of biomedical and tissue engineering.
Bibliographical noteFunding Information:
Y.K.J., H.J.K., and Y.J. contributed equally to this work. This work was financially supported by the Marine Biomaterials Research Center grant from Marine Biotechnology Program of the Korea Institute of Marine Science & Technology Promotion funded by the Ministry of Oceans and Fisheries, Korea. This article is part of the Advanced Materials Interfaces Hall of Fame article series, which highlights the work of top interface and surface scientists.
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
- biomolecule immobilization
- recombinant mussel adhesive proteins
- surface coatings
- surface engineering