Biomimetic Surface Engineering of Biomaterials by Using Recombinant Mussel Adhesive Proteins

Yun Kee Jo, Hyo Jeong Kim, Yeonsu Jeong, Kye Il Joo, Hyung Joon Cha

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations


Surface engineering is a key approach for tailoring new functionalities into biomaterials to achieve better clinical performance. The rise of genetic engineering and molecular biotechnology made it possible to design artificial sticky proteins derived from marine mussels that are capable of firmly anchoring on a variety of substrates with high binding strength, opening a new route for surface engineering of biomaterials. Coatings of recombinant mussel adhesive proteins (MAPs) have aroused great interest for the surface functionalization of biomaterials due to their simplicity, versatility, and high stability under physiological conditions, as well as their favorable interactions with cells. In addition, recombinant MAPs can be engineered to provide desired specific functionalities on target surfaces by genetic fusion with functional peptides and/or by the immobilization of biomolecules. This review provides an overview of recombinant MAPs-based surface coatings, highlighting their mechanisms, characteristic surface properties, and diverse applications in providing bioengineered surfaces in the fields of biomedical and tissue engineering.

Original languageEnglish
Article number1800068
JournalAdvanced Materials Interfaces
Issue number9
StatePublished - 9 May 2018

Bibliographical note

Publisher Copyright:
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim


  • biomaterials
  • biomolecule immobilization
  • recombinant mussel adhesive proteins
  • surface coatings
  • surface engineering


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