Bioinspired nanocorals with decoupled cellular targeting and sensing functionality

Liz Y. Wu, Benjamin M. Ross, Soon Gweon Hong, Luke P. Lee

Research output: Contribution to journalArticlepeer-review

131 Scopus citations

Abstract

Nanocorals demonstrate independent cell-targeting and label-free biomolecular sensing capabilities. The highly roughened gold region of the nanocoral increases the adsorption capacity and causes a strong surface-enhanced Raman spectroscopy (SERS) signal. The polystyrene region can adsorb antibodies, allowing the nanocoral to specifically bind to receptors on the cancer cell membrane making nanocorals multifunctional nanosensors for cellular diagnostics and treatment evaluation.

Original languageEnglish
Pages (from-to)503-507
Number of pages5
JournalSmall
Volume6
Issue number4
DOIs
StatePublished - 22 Feb 2010

Keywords

  • Cellular sensing
  • Molecular recognition
  • Nanoplasmonic probes
  • Optical antennas
  • Surface-enhanced Raman spectroscopy (SERS)

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