Bioenergetics of aging and calorie restriction

Nicole D. Hunt; Dong Hoon Hyun; Joanne S. Allard; Robin K. Minor; Mark P. Mattson; Donald K. Ingram; Rafael de Cabo

doi:10.1016/j.arr.2006.03.006

Bioenergetics of aging and calorie restriction

Nicole D. Hunt, Dong Hoon Hyun, Joanne S. Allard, Robin K. Minor, Mark P. Mattson, Donald K. Ingram, Rafael de Cabo

Department of Life Science

Research output: Contribution to journal › Short survey › peer-review

58 Scopus citations

Abstract

Aging is a physiological process that involves a multi-factorial set of deleterious changes. These alterations are caused by an exponential increase in damage to macromolecules. This process is likely due to the cumulative effects of oxidative stress over time. One area of ongoing research in gerontology has focused on determining why there is an age-dependent decrease in cellular bioenergetics. The aim of this review is to summarize the recent findings on the effects of aging and calorie restriction on energy metabolism. The effect of calorie restriction on age-associated changes in bioenergetic parameters will be examined.

Original language	English
Pages (from-to)	125-143
Number of pages	19
Journal	Ageing Research Reviews
Volume	5
Issue number	2
DOIs	https://doi.org/10.1016/j.arr.2006.03.006
State	Published - May 2006

Keywords

Aging
Bioenergetics
Calorie restriction
Oxidative damage

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title = "Bioenergetics of aging and calorie restriction",

abstract = "Aging is a physiological process that involves a multi-factorial set of deleterious changes. These alterations are caused by an exponential increase in damage to macromolecules. This process is likely due to the cumulative effects of oxidative stress over time. One area of ongoing research in gerontology has focused on determining why there is an age-dependent decrease in cellular bioenergetics. The aim of this review is to summarize the recent findings on the effects of aging and calorie restriction on energy metabolism. The effect of calorie restriction on age-associated changes in bioenergetic parameters will be examined.",

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AU - Hunt, Nicole D.

AU - Hyun, Dong Hoon

AU - Allard, Joanne S.

AU - Minor, Robin K.

AU - Mattson, Mark P.

AU - Ingram, Donald K.

AU - de Cabo, Rafael

PY - 2006/5

Y1 - 2006/5

N2 - Aging is a physiological process that involves a multi-factorial set of deleterious changes. These alterations are caused by an exponential increase in damage to macromolecules. This process is likely due to the cumulative effects of oxidative stress over time. One area of ongoing research in gerontology has focused on determining why there is an age-dependent decrease in cellular bioenergetics. The aim of this review is to summarize the recent findings on the effects of aging and calorie restriction on energy metabolism. The effect of calorie restriction on age-associated changes in bioenergetic parameters will be examined.

AB - Aging is a physiological process that involves a multi-factorial set of deleterious changes. These alterations are caused by an exponential increase in damage to macromolecules. This process is likely due to the cumulative effects of oxidative stress over time. One area of ongoing research in gerontology has focused on determining why there is an age-dependent decrease in cellular bioenergetics. The aim of this review is to summarize the recent findings on the effects of aging and calorie restriction on energy metabolism. The effect of calorie restriction on age-associated changes in bioenergetic parameters will be examined.

KW - Aging

KW - Bioenergetics

KW - Calorie restriction

KW - Oxidative damage

UR - http://www.scopus.com/inward/record.url?scp=33646820690&partnerID=8YFLogxK

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SN - 1568-1637

VL - 5

SP - 125

EP - 143

JO - Ageing Research Reviews

JF - Ageing Research Reviews

IS - 2

ER -

Bioenergetics of aging and calorie restriction

Abstract

Keywords

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