Bioenergetics of aging and calorie restriction

Nicole D. Hunt, Dong Hoon Hyun, Joanne S. Allard, Robin K. Minor, Mark P. Mattson, Donald K. Ingram, Rafael de Cabo

Research output: Contribution to journalShort surveypeer-review

58 Scopus citations


Aging is a physiological process that involves a multi-factorial set of deleterious changes. These alterations are caused by an exponential increase in damage to macromolecules. This process is likely due to the cumulative effects of oxidative stress over time. One area of ongoing research in gerontology has focused on determining why there is an age-dependent decrease in cellular bioenergetics. The aim of this review is to summarize the recent findings on the effects of aging and calorie restriction on energy metabolism. The effect of calorie restriction on age-associated changes in bioenergetic parameters will be examined.

Original languageEnglish
Pages (from-to)125-143
Number of pages19
JournalAgeing Research Reviews
Issue number2
StatePublished - May 2006


  • Aging
  • Bioenergetics
  • Calorie restriction
  • Oxidative damage


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