"Bioelectronic super-taster" device based on taste receptor-carbon nanotube hybrid structures

Tae Hyun Kim, Hyun Seok Song, Hye Jun Jin, Sang Hun Lee, Seon Namgung, Un Kyung Kim, Tai Hyun Park, Seunghun Hong

Research output: Contribution to journalArticlepeer-review

69 Scopus citations


We have developed a method to monitor the activities of human taste receptor protein in lipid membrane using carbon nanotube transistors, enabling a "bioelectronic super-taster (BST)", a taste sensor with human-tongue-like selectivity. In this work, human bitter taste receptor protein expressed in E. coli was immobilized on a single-walled carbon nanotube field effect transistor (swCNT-FET) with the lipid membrane. Then, the protein binding activity was monitored using the underlying swCNT-FET, leading to the operation as a BST device. The fabricated BST device could detect bitter tastants at 100 fM concentrations and distinguish between bitter and non-bitter tastants with similar chemical structures just like a human tongue. Furthermore, this strategy was utilized to differentiate the responses of taster or non-taster types of the bitter taste receptor proteins.

Original languageEnglish
Pages (from-to)2262-2267
Number of pages6
JournalLab on a Chip
Issue number13
StatePublished - 7 Jul 2011


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