Bioelectronic Skin Based on Nociceptive Ion Channel for Human-Like Perception of Cold Pains

Narae Shin, Seung Hwan Lee, Youngtak Cho, Tai Hyun Park, Seunghun Hong

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

A bioelectronic skin device based on nociceptive ion channels in nanovesicles is developed for the detection of chemical cold-pain stimuli and cold environments just like human somesthetic sensory systems. The human transient receptor potential ankyrin 1 (hTRPA1) is involved in transmission and modulation of cold-pain sensations. In the bioelectronic skin, the nanovesicles containing the hTRPA1 nociceptive ion channel protein reacts to cold-pain stimuli, and it is electrically monitored through carbon nanotube transistor devices based on floating electrodes. The bioelectronic skin devices sensitively detect chemical cold-pain stimuli like cinnamaldehyde at 10 fm, and selectively discriminate cinnamaldehyde among other chemical stimuli. Further, the bioelectronic skin is used to evaluate the effect of cold environments on the response of the hTRPA1, finding that the nociceptive ion channel responds more sensitively to cinnamaldehyde at lower temperatures than at higher temperatures. The bioelectronic skin device could be useful for a basic study on somesthetic systems such as cold-pain sensation, and should be used for versatile applications such as screening of foods and drugs.

Original languageEnglish
Article number2001469
JournalSmall
Volume16
Issue number30
DOIs
StatePublished - 1 Jul 2020

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (MSIT) of Korea (nos. 2013M3A6B2078961, 2018R1A2B3004498, 2018R1C1B5085757), the Ministry of Education (no. 2018R1A6A1A03024231), and the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 682286). S.H. also acknowledges the support from the Samsung Electronics and the National Research Foundation of Korea (no. 2020R1A2B5B02002152). This work was also supported by KIST Institutional Program (no. 2E29530).

Publisher Copyright:
© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

  • bioelectronic skins
  • carbon nanotube field-effect transistors
  • cinnamaldehyde
  • human transient receptor potential ankyrin 1
  • nanovesicles
  • nociceptive ion channels

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