Biodegradable thermosensitive micelles of PEG-PLGA-PEG triblock copolymers

Byeongmoon Jeong; You Han Bae; Sung Wan Kim

doi:10.1016/S0927-7765(99)00069-7

Biodegradable thermosensitive micelles of PEG-PLGA-PEG triblock copolymers

Byeongmoon Jeong, You Han Bae, Sung Wan Kim

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

198 Scopus citations

Abstract

Micellization of poly(ethylene glycol-b-(DL-lactic acid-co-glycolic acid)-b-ethylene glycol), PEG-PLGA-PEG, triblock copolymers in water was studied by ¹³C-NMR (nuclear magnetic resonance), dye solubilization method, and light scattering. Critical micelle concentration was decreased by half by increasing temperature from 20 to 50°C. Enthalpy of micellization was calculated to be 10-20 KJ/mole. Apparent aggregation number, diameter of a micelle abruptly increased while second viral coefficient decreased at ≃ 30°C suggesting that micellar growth as well as an increase in polymer- polymer attraction occur at this temperature. These findings might suggest that the sol to gel transition at high concentration of aqueous solutions of this polymer is driven by conformational changes of micelles.

Original language	English
Pages (from-to)	185-193
Number of pages	9
Journal	Colloids and Surfaces B: Biointerfaces
Volume	16
Issue number	1-4
DOIs	https://doi.org/10.1016/S0927-7765(99)00069-7
State	Published - Nov 1999

Bibliographical note

Funding Information:
This work was supported by the University of Utah Research Foundation and NIH grant GM 56098.

Keywords

Biodegradable
Block copolymer
Micelle
PEG-PLGA-PEG
Thermosensitive

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10.1016/S0927-7765(99)00069-7

Cite this

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title = "Biodegradable thermosensitive micelles of PEG-PLGA-PEG triblock copolymers",

abstract = "Micellization of poly(ethylene glycol-b-(DL-lactic acid-co-glycolic acid)-b-ethylene glycol), PEG-PLGA-PEG, triblock copolymers in water was studied by 13C-NMR (nuclear magnetic resonance), dye solubilization method, and light scattering. Critical micelle concentration was decreased by half by increasing temperature from 20 to 50°C. Enthalpy of micellization was calculated to be 10-20 KJ/mole. Apparent aggregation number, diameter of a micelle abruptly increased while second viral coefficient decreased at ≃ 30°C suggesting that micellar growth as well as an increase in polymer- polymer attraction occur at this temperature. These findings might suggest that the sol to gel transition at high concentration of aqueous solutions of this polymer is driven by conformational changes of micelles.",

keywords = "Biodegradable, Block copolymer, Micelle, PEG-PLGA-PEG, Thermosensitive",

author = "Byeongmoon Jeong and {Han Bae}, You and {Wan Kim}, Sung",

note = "Funding Information: This work was supported by the University of Utah Research Foundation and NIH grant GM 56098.",

year = "1999",

month = nov,

doi = "10.1016/S0927-7765(99)00069-7",

language = "English",

volume = "16",

pages = "185--193",

journal = "Colloids and Surfaces B: Biointerfaces",

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publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Biodegradable thermosensitive micelles of PEG-PLGA-PEG triblock copolymers

AU - Jeong, Byeongmoon

AU - Han Bae, You

AU - Wan Kim, Sung

N1 - Funding Information: This work was supported by the University of Utah Research Foundation and NIH grant GM 56098.

PY - 1999/11

Y1 - 1999/11

N2 - Micellization of poly(ethylene glycol-b-(DL-lactic acid-co-glycolic acid)-b-ethylene glycol), PEG-PLGA-PEG, triblock copolymers in water was studied by 13C-NMR (nuclear magnetic resonance), dye solubilization method, and light scattering. Critical micelle concentration was decreased by half by increasing temperature from 20 to 50°C. Enthalpy of micellization was calculated to be 10-20 KJ/mole. Apparent aggregation number, diameter of a micelle abruptly increased while second viral coefficient decreased at ≃ 30°C suggesting that micellar growth as well as an increase in polymer- polymer attraction occur at this temperature. These findings might suggest that the sol to gel transition at high concentration of aqueous solutions of this polymer is driven by conformational changes of micelles.

AB - Micellization of poly(ethylene glycol-b-(DL-lactic acid-co-glycolic acid)-b-ethylene glycol), PEG-PLGA-PEG, triblock copolymers in water was studied by 13C-NMR (nuclear magnetic resonance), dye solubilization method, and light scattering. Critical micelle concentration was decreased by half by increasing temperature from 20 to 50°C. Enthalpy of micellization was calculated to be 10-20 KJ/mole. Apparent aggregation number, diameter of a micelle abruptly increased while second viral coefficient decreased at ≃ 30°C suggesting that micellar growth as well as an increase in polymer- polymer attraction occur at this temperature. These findings might suggest that the sol to gel transition at high concentration of aqueous solutions of this polymer is driven by conformational changes of micelles.

KW - Biodegradable

KW - Block copolymer

KW - Micelle

KW - PEG-PLGA-PEG

KW - Thermosensitive

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U2 - 10.1016/S0927-7765(99)00069-7

DO - 10.1016/S0927-7765(99)00069-7

M3 - Article

AN - SCOPUS:0345411651

SN - 0927-7765

VL - 16

SP - 185

EP - 193

JO - Colloids and Surfaces B: Biointerfaces

JF - Colloids and Surfaces B: Biointerfaces

IS - 1-4

ER -

Biodegradable thermosensitive micelles of PEG-PLGA-PEG triblock copolymers

Abstract

Bibliographical note

Keywords

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