Biodegradable thermosensitive micelles of PEG-PLGA-PEG triblock copolymers

Byeongmoon Jeong, You Han Bae, Sung Wan Kim

Research output: Contribution to journalArticlepeer-review

187 Scopus citations

Abstract

Micellization of poly(ethylene glycol-b-(DL-lactic acid-co-glycolic acid)-b-ethylene glycol), PEG-PLGA-PEG, triblock copolymers in water was studied by 13C-NMR (nuclear magnetic resonance), dye solubilization method, and light scattering. Critical micelle concentration was decreased by half by increasing temperature from 20 to 50°C. Enthalpy of micellization was calculated to be 10-20 KJ/mole. Apparent aggregation number, diameter of a micelle abruptly increased while second viral coefficient decreased at ≃ 30°C suggesting that micellar growth as well as an increase in polymer- polymer attraction occur at this temperature. These findings might suggest that the sol to gel transition at high concentration of aqueous solutions of this polymer is driven by conformational changes of micelles.

Original languageEnglish
Pages (from-to)185-193
Number of pages9
JournalColloids and Surfaces B: Biointerfaces
Volume16
Issue number1-4
DOIs
StatePublished - Nov 1999

Keywords

  • Biodegradable
  • Block copolymer
  • Micelle
  • PEG-PLGA-PEG
  • Thermosensitive

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