Bioactive sesterterpenoids from a Korean sponge monanchora sp.

Weihong Wang, Bora Mun, Yehee Lee, Mallepally Venkat Reddy, Youngmin Park, Jihye Lee, Hiyoung Kim, Dongyup Hahn, Jungwook Chin, Merrick Ekins, Sang Jip Nam, Heonjoong Kang

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Chemical investigation of a Korean marine sponge, Monanchora sp., yielded nine new sesterterpenoids (1-9) along with phorbaketals A-C (10-12). The planar structures were established on the basis of NMR and MS analysis, and the absolute configurations of 1-9 were defined using the modified Mosher's method and CD spectroscopic data analysis. Compounds 1-8, designated as phorbaketals D-K, possess a spiroketal-modified benzopyran moiety such as phorbaketal A, and their structural variations are due to oxidation and/or reduction of the tricyclic core or the side chain. Compound 9, designated as phorbin A, has a monocyclic structure and is proposed to be a possible biogenetic precursor of the phorbaketals. Compounds 1-9 were evaluated for cytotoxicity against four human cancer cell lines (A498, ACHN, MIA-paca, and PANC-1), and a few of them were found to exhibit cytotoxic activity.

Original languageEnglish
Pages (from-to)170-177
Number of pages8
JournalJournal of Natural Products
Volume76
Issue number2
DOIs
StatePublished - 22 Feb 2013

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