Bioactive prenylated flavonoids from the stem bark of Artocarpus kemando

Eun Kyoung Seo; Dongho Lee; Geun Shin Young; Hee Byung Chai; Hernán A. Navarro; Leonardus B.S. Kardono; Ismail Rahman; Geoffrey A. Cordell; Norman R. Farnsworth; John M. Pezzuto; A. Douglas Kinghorn; Mansukh C. Wani; Monroe E. Wall

doi:10.1007/bf02976656

Bioactive prenylated flavonoids from the stem bark of Artocarpus kemando

Eun Kyoung Seo, Dongho Lee, Geun Shin Young, Hee Byung Chai, Hernán A. Navarro, Leonardus B.S. Kardono, Ismail Rahman, Geoffrey A. Cordell, Norman R. Farnsworth, John M. Pezzuto, A. Douglas Kinghorn, Mansukh C. Wani, Monroe E. Wall

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Four known prenylated flavonoids, artonins E (1) and O (2), artobiloxanthone (3), and cycloartobiloxanthone (4), were isolated from the stem bark of Artocarpus kemando by bioassay-guided fractionation using the DNA strand-scission and the KB cytotoxicity assays as monitors. Compounds 1 and 3 exhibited strong DNA strand-scission activity, and all four compounds were found to be cytotoxic.

Original language	English
Pages (from-to)	124-127
Number of pages	4
Journal	Archives of Pharmacal Research
Volume	26
Issue number	2
DOIs	https://doi.org/10.1007/bf02976656
State	Published - 28 Feb 2003

Keywords

Artocarpus kemando
Cytotoxicity
DNA strand-scission activity
Flavonoids
LC-MS dereplication
Moraceae

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10.1007/bf02976656

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title = "Bioactive prenylated flavonoids from the stem bark of Artocarpus kemando",

abstract = "Four known prenylated flavonoids, artonins E (1) and O (2), artobiloxanthone (3), and cycloartobiloxanthone (4), were isolated from the stem bark of Artocarpus kemando by bioassay-guided fractionation using the DNA strand-scission and the KB cytotoxicity assays as monitors. Compounds 1 and 3 exhibited strong DNA strand-scission activity, and all four compounds were found to be cytotoxic.",

keywords = "Artocarpus kemando, Cytotoxicity, DNA strand-scission activity, Flavonoids, LC-MS dereplication, Moraceae",

author = "Seo, {Eun Kyoung} and Dongho Lee and Young, {Geun Shin} and Chai, {Hee Byung} and Navarro, {Hern{\'a}n A.} and Kardono, {Leonardus B.S.} and Ismail Rahman and Cordell, {Geoffrey A.} and Farnsworth, {Norman R.} and Pezzuto, {John M.} and Kinghorn, {A. Douglas} and Wani, {Mansukh C.} and Wall, {Monroe E.}",

year = "2003",

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doi = "10.1007/bf02976656",

language = "English",

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TY - JOUR

T1 - Bioactive prenylated flavonoids from the stem bark of Artocarpus kemando

AU - Seo, Eun Kyoung

AU - Lee, Dongho

AU - Young, Geun Shin

AU - Chai, Hee Byung

AU - Navarro, Hernán A.

AU - Kardono, Leonardus B.S.

AU - Rahman, Ismail

AU - Cordell, Geoffrey A.

AU - Farnsworth, Norman R.

AU - Pezzuto, John M.

AU - Kinghorn, A. Douglas

AU - Wani, Mansukh C.

AU - Wall, Monroe E.

PY - 2003/2/28

Y1 - 2003/2/28

N2 - Four known prenylated flavonoids, artonins E (1) and O (2), artobiloxanthone (3), and cycloartobiloxanthone (4), were isolated from the stem bark of Artocarpus kemando by bioassay-guided fractionation using the DNA strand-scission and the KB cytotoxicity assays as monitors. Compounds 1 and 3 exhibited strong DNA strand-scission activity, and all four compounds were found to be cytotoxic.

AB - Four known prenylated flavonoids, artonins E (1) and O (2), artobiloxanthone (3), and cycloartobiloxanthone (4), were isolated from the stem bark of Artocarpus kemando by bioassay-guided fractionation using the DNA strand-scission and the KB cytotoxicity assays as monitors. Compounds 1 and 3 exhibited strong DNA strand-scission activity, and all four compounds were found to be cytotoxic.

KW - Artocarpus kemando

KW - Cytotoxicity

KW - DNA strand-scission activity

KW - Flavonoids

KW - LC-MS dereplication

KW - Moraceae

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EP - 127

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 2

ER -

Bioactive prenylated flavonoids from the stem bark of Artocarpus kemando

Abstract

Keywords

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