Bioactive natural products from the genus Salinospora: a review

Haerin Kim, Sohee Kim, Minju Kim, Chaeyoung Lee, Inho Yang, Sang Jip Nam

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Actinomycetes are an important source for bioactive secondary metabolites. Among them, the genus Salinispora is one of the first salt obligatory marine species worldwide and is typically found in various types of substrates in tropical and subtropical marine environments including sediments and marine organisms. This genus produces a wide range of chemical scaffolds and bioactive compounds such as lomaiviticins, cyclomarins, rifamycins, salinaphthoquinones, and salinosporamides. This review arranged Salinispora derived secondary metabolites according to the three species that comprise the genus. Moreover, muta- and semi-synthesis analogs derived from salinosporamide were also described in this review.

Original languageEnglish
Pages (from-to)1230-1258
Number of pages29
JournalArchives of Pharmacal Research
Volume43
Issue number12
DOIs
StatePublished - Dec 2020

Keywords

  • Actinomycetes
  • Marine natural products
  • Salinispora
  • Salinispora arenicola
  • Salinispora pacifica
  • Salinispora tropica

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