TY - JOUR
T1 - Bioactive multilayer thin films of charged N,N-disubstituted hydrazine phosphorus dendrimers fabricated by layer-by-layer self-assembly
AU - Hernandez-Lopez, Jose Luis
AU - Khor, Hwei Ling
AU - Caminade, Anne Marie
AU - Majoral, Jean Pierre
AU - Mittler, Silvia
AU - Knoll, Wolfgang
AU - Kim, Dong Ha
N1 - Funding Information:
This work was supported by the Seoul Research and Business Development Program (10816). Financial support from Deutsche Forschungsgemeinschaft (MU 334/22-2, and SFB 625) is gratefully acknowledged. Prof. J.-P. Majoral and Dr. A. M. Caminade thank CNRS (France) for financial support. The authors thank Melanie Jungblut at the Max Planck Institute for Polymer Research for the preparation of fetal cortical neurons.
PY - 2008/1/30
Y1 - 2008/1/30
N2 - Charged N,N-disubstituted hydrazine phosphorus-containing dendrimers are deposited either as alternate all-dendrimers multilayers or alternating with linear polymers on 3-mercaptopropionic acid or 3-aminopropyldimethylethoxysilane coated surfaces via electrostatic layer-by-layer self-assembly. The behavior of the film formation is investigated by surface plasmon resonance spectroscopy and ellipsometry. Fetal cortical rat neurons were cultured on the dendrimer films in order to investigate the influence of the surface charge of the outermost layer on their adhesion and maturation. It was found that neurons attached preferentially and matured slightly faster on film surfaces terminated with positively charged dendrimers than on negatively charged surfaces.
AB - Charged N,N-disubstituted hydrazine phosphorus-containing dendrimers are deposited either as alternate all-dendrimers multilayers or alternating with linear polymers on 3-mercaptopropionic acid or 3-aminopropyldimethylethoxysilane coated surfaces via electrostatic layer-by-layer self-assembly. The behavior of the film formation is investigated by surface plasmon resonance spectroscopy and ellipsometry. Fetal cortical rat neurons were cultured on the dendrimer films in order to investigate the influence of the surface charge of the outermost layer on their adhesion and maturation. It was found that neurons attached preferentially and matured slightly faster on film surfaces terminated with positively charged dendrimers than on negatively charged surfaces.
KW - Cell adhesion
KW - Layer-by-layer self-assembly
KW - Phosphorus dendrimer
KW - Surface plasmon resonance
UR - http://www.scopus.com/inward/record.url?scp=37349024800&partnerID=8YFLogxK
U2 - 10.1016/j.tsf.2007.05.049
DO - 10.1016/j.tsf.2007.05.049
M3 - Article
AN - SCOPUS:37349024800
SN - 0040-6090
VL - 516
SP - 1256
EP - 1264
JO - Thin Solid Films
JF - Thin Solid Films
IS - 6
ER -