Bioactive multilayer thin films of charged N,N-disubstituted hydrazine phosphorus dendrimers fabricated by layer-by-layer self-assembly

Jose Luis Hernandez-Lopez; Hwei Ling Khor; Anne Marie Caminade; Jean Pierre Majoral; Silvia Mittler; Wolfgang Knoll; Dong Ha Kim

doi:10.1016/j.tsf.2007.05.049

Bioactive multilayer thin films of charged N,N-disubstituted hydrazine phosphorus dendrimers fabricated by layer-by-layer self-assembly

Jose Luis Hernandez-Lopez, Hwei Ling Khor, Anne Marie Caminade, Jean Pierre Majoral, Silvia Mittler, Wolfgang Knoll, Dong Ha Kim

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Charged N,N-disubstituted hydrazine phosphorus-containing dendrimers are deposited either as alternate all-dendrimers multilayers or alternating with linear polymers on 3-mercaptopropionic acid or 3-aminopropyldimethylethoxysilane coated surfaces via electrostatic layer-by-layer self-assembly. The behavior of the film formation is investigated by surface plasmon resonance spectroscopy and ellipsometry. Fetal cortical rat neurons were cultured on the dendrimer films in order to investigate the influence of the surface charge of the outermost layer on their adhesion and maturation. It was found that neurons attached preferentially and matured slightly faster on film surfaces terminated with positively charged dendrimers than on negatively charged surfaces.

Original language	English
Pages (from-to)	1256-1264
Number of pages	9
Journal	Thin Solid Films
Volume	516
Issue number	6
DOIs	https://doi.org/10.1016/j.tsf.2007.05.049
State	Published - 30 Jan 2008

Bibliographical note

Funding Information:
This work was supported by the Seoul Research and Business Development Program (10816). Financial support from Deutsche Forschungsgemeinschaft (MU 334/22-2, and SFB 625) is gratefully acknowledged. Prof. J.-P. Majoral and Dr. A. M. Caminade thank CNRS (France) for financial support. The authors thank Melanie Jungblut at the Max Planck Institute for Polymer Research for the preparation of fetal cortical neurons.

Keywords

Cell adhesion
Layer-by-layer self-assembly
Phosphorus dendrimer
Surface plasmon resonance

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title = "Bioactive multilayer thin films of charged N,N-disubstituted hydrazine phosphorus dendrimers fabricated by layer-by-layer self-assembly",

abstract = "Charged N,N-disubstituted hydrazine phosphorus-containing dendrimers are deposited either as alternate all-dendrimers multilayers or alternating with linear polymers on 3-mercaptopropionic acid or 3-aminopropyldimethylethoxysilane coated surfaces via electrostatic layer-by-layer self-assembly. The behavior of the film formation is investigated by surface plasmon resonance spectroscopy and ellipsometry. Fetal cortical rat neurons were cultured on the dendrimer films in order to investigate the influence of the surface charge of the outermost layer on their adhesion and maturation. It was found that neurons attached preferentially and matured slightly faster on film surfaces terminated with positively charged dendrimers than on negatively charged surfaces.",

keywords = "Cell adhesion, Layer-by-layer self-assembly, Phosphorus dendrimer, Surface plasmon resonance",

author = "Hernandez-Lopez, {Jose Luis} and Khor, {Hwei Ling} and Caminade, {Anne Marie} and Majoral, {Jean Pierre} and Silvia Mittler and Wolfgang Knoll and Kim, {Dong Ha}",

note = "Funding Information: This work was supported by the Seoul Research and Business Development Program (10816). Financial support from Deutsche Forschungsgemeinschaft (MU 334/22-2, and SFB 625) is gratefully acknowledged. Prof. J.-P. Majoral and Dr. A. M. Caminade thank CNRS (France) for financial support. The authors thank Melanie Jungblut at the Max Planck Institute for Polymer Research for the preparation of fetal cortical neurons.",

year = "2008",

month = jan,

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doi = "10.1016/j.tsf.2007.05.049",

language = "English",

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AU - Hernandez-Lopez, Jose Luis

AU - Khor, Hwei Ling

AU - Caminade, Anne Marie

AU - Majoral, Jean Pierre

AU - Mittler, Silvia

AU - Knoll, Wolfgang

AU - Kim, Dong Ha

N1 - Funding Information: This work was supported by the Seoul Research and Business Development Program (10816). Financial support from Deutsche Forschungsgemeinschaft (MU 334/22-2, and SFB 625) is gratefully acknowledged. Prof. J.-P. Majoral and Dr. A. M. Caminade thank CNRS (France) for financial support. The authors thank Melanie Jungblut at the Max Planck Institute for Polymer Research for the preparation of fetal cortical neurons.

PY - 2008/1/30

Y1 - 2008/1/30

N2 - Charged N,N-disubstituted hydrazine phosphorus-containing dendrimers are deposited either as alternate all-dendrimers multilayers or alternating with linear polymers on 3-mercaptopropionic acid or 3-aminopropyldimethylethoxysilane coated surfaces via electrostatic layer-by-layer self-assembly. The behavior of the film formation is investigated by surface plasmon resonance spectroscopy and ellipsometry. Fetal cortical rat neurons were cultured on the dendrimer films in order to investigate the influence of the surface charge of the outermost layer on their adhesion and maturation. It was found that neurons attached preferentially and matured slightly faster on film surfaces terminated with positively charged dendrimers than on negatively charged surfaces.

AB - Charged N,N-disubstituted hydrazine phosphorus-containing dendrimers are deposited either as alternate all-dendrimers multilayers or alternating with linear polymers on 3-mercaptopropionic acid or 3-aminopropyldimethylethoxysilane coated surfaces via electrostatic layer-by-layer self-assembly. The behavior of the film formation is investigated by surface plasmon resonance spectroscopy and ellipsometry. Fetal cortical rat neurons were cultured on the dendrimer films in order to investigate the influence of the surface charge of the outermost layer on their adhesion and maturation. It was found that neurons attached preferentially and matured slightly faster on film surfaces terminated with positively charged dendrimers than on negatively charged surfaces.

KW - Cell adhesion

KW - Layer-by-layer self-assembly

KW - Phosphorus dendrimer

KW - Surface plasmon resonance

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SN - 0040-6090

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ER -

Bioactive multilayer thin films of charged N,N-disubstituted hydrazine phosphorus dendrimers fabricated by layer-by-layer self-assembly

Abstract

Bibliographical note

Keywords

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