Bio-functionalization of metal-organic frameworks by covalent protein conjugation

Suhyun Jung; Youngmee Kim; Sung Jin Kim; Tae Hwan Kwon; Seong Huh; Seongsoon Park

doi:10.1039/c0cc03288c

Bio-functionalization of metal-organic frameworks by covalent protein conjugation

Suhyun Jung, Youngmee Kim, Sung Jin Kim, Tae Hwan Kwon, Seong Huh, Seongsoon Park

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

233 Scopus citations

Abstract

Bioconjugation of functional proteins onto metal-organic frameworks (MOFs) has been achieved using activation of pendent linking groups of the organic linkers on the surface of MOFs. Fluorescent microscopy revealed successful conjugation of an enhanced fluorescent protein onto MOFs. In addition, Candida-antarctica-lipase-B-conjugated MOFs showed no loss of enantioselectivity and activity in transesterification of (±)-1-phenylethanol.

Original language	English
Pages (from-to)	2904-2906
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	10
DOIs	https://doi.org/10.1039/c0cc03288c
State	Published - 21 Feb 2011

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title = "Bio-functionalization of metal-organic frameworks by covalent protein conjugation",

abstract = "Bioconjugation of functional proteins onto metal-organic frameworks (MOFs) has been achieved using activation of pendent linking groups of the organic linkers on the surface of MOFs. Fluorescent microscopy revealed successful conjugation of an enhanced fluorescent protein onto MOFs. In addition, Candida-antarctica-lipase-B-conjugated MOFs showed no loss of enantioselectivity and activity in transesterification of (±)-1-phenylethanol.",

author = "Suhyun Jung and Youngmee Kim and Kim, {Sung Jin} and Kwon, {Tae Hwan} and Seong Huh and Seongsoon Park",

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T1 - Bio-functionalization of metal-organic frameworks by covalent protein conjugation

AU - Jung, Suhyun

AU - Kim, Youngmee

AU - Kim, Sung Jin

AU - Kwon, Tae Hwan

AU - Huh, Seong

AU - Park, Seongsoon

PY - 2011/2/21

Y1 - 2011/2/21

N2 - Bioconjugation of functional proteins onto metal-organic frameworks (MOFs) has been achieved using activation of pendent linking groups of the organic linkers on the surface of MOFs. Fluorescent microscopy revealed successful conjugation of an enhanced fluorescent protein onto MOFs. In addition, Candida-antarctica-lipase-B-conjugated MOFs showed no loss of enantioselectivity and activity in transesterification of (±)-1-phenylethanol.

AB - Bioconjugation of functional proteins onto metal-organic frameworks (MOFs) has been achieved using activation of pendent linking groups of the organic linkers on the surface of MOFs. Fluorescent microscopy revealed successful conjugation of an enhanced fluorescent protein onto MOFs. In addition, Candida-antarctica-lipase-B-conjugated MOFs showed no loss of enantioselectivity and activity in transesterification of (±)-1-phenylethanol.

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U2 - 10.1039/c0cc03288c

DO - 10.1039/c0cc03288c

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SP - 2904

EP - 2906

JO - Chemical Communications

JF - Chemical Communications

IS - 10

ER -

Bio-functionalization of metal-organic frameworks by covalent protein conjugation

Abstract

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