Bio-barcodes based on oligonucleotide-modified nanoparticles

Jwa Min Nam, So Jung Park, Chad A. Mirkin

Research output: Contribution to journalArticlepeer-review

276 Scopus citations


By utilizing oligonucleotide-modified Au nanoparticles encoded with sequences that act as biobarcodes, one can screen for multiple target polyvalent proteins simultaneously in one solution. This novel concept was demonstrated with two types of detection formats, a homogeneous assay and one based on oligonucleotide microarrays. With such an approach, one can prepare an extraordinarily large number of barcodes from synthetically accessible oligonucleotides (e.g., a 12-mer sequence offers 412 possible barcodes).

Original languageEnglish
Pages (from-to)3820-3821
Number of pages2
JournalJournal of the American Chemical Society
Issue number15
StatePublished - 17 Apr 2002


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