Binding mode analysis of topoisomerase inhibitors, 6-arylamino-7-chloro- quinazoline-5,8-diones, within the cleavable complex of human topoisomerase I and DNA

Chemical Compounds

• Topoisomerase Inhibitor 89%
• 1,4-naphthoquinone 72%
• Compound Type 69%
• Camptothecin 68%
• Antitumor 49%
• Hydrogen Bond 32%
• Crystal Structure 26%
• Molecule 18%

Medicine & Life Sciences

• human TOP1 protein 100%
• Quinazolines 82%
• Topoisomerase Inhibitors 80%
• DNA 29%
• Base Pairing 15%
• 1,4-naphthoquinone 12%
• Topoisomerase I Inhibitors 10%
• Camptothecin 9%
• Hydrogen Bonding 9%
• Hydrophobic and Hydrophilic Interactions 8%
• In Vitro Techniques 6%
• Plasmids 6%
• X-Rays 5%
• Water 5%