@article{44f7c3f927774aada14e0a49c729cf89,
title = "Bimetallic nanopetals for thousand-fold fluorescence enhancements",
abstract = "We present a simple, ultra-rapid and robust method to create sharp nanostructures-nanopetals-in a shape memory polymer substrate demonstrating unprecedented enhancements for surface enhanced sensing over large surface areas. These bimetallic nanostructures demonstrate extremely strong surface plasmon resonance effects due to the high density multifaceted petal structures that increase the probability of forming nanogaps. We demonstrate that our nanopetals exhibit extremely strong surface plasmons, confining the emission and enhancing the fluorescence intensity of the nearby high-quantum yield fluorescein by >4000×. The enhancements are confined to the extremely small volumes at the nanopetal borders. This enables us to achieve single molecule detection at relatively high and physiological concentrations.",
author = "Fu, {Chi Cheng} and Giulia Ossato and Maureen Long and Digman, {Michelle A.} and Ajay Gopinathan and Lee, {Luke P.} and Enrico Gratton and Michelle Khine",
note = "Funding Information: Authors Fu & Ossato contributed equally to this work. Supported by NIH-P41 under Grant No. P41-RRO3155 (E.G. and G.O.), under Grant No. U54 GM064346 Cell Migration Consortium (M.D. and E.G.), UC Cancer Support under Grant No. CA-62203 (M.D.) through the Developmental Biology Center{\textquoteright}s Biology Optical Core Facility, and Shrink Nanotechnologies Inc. The author Khine is the scientific founder of Shrink but receives no compensation nor does she have any financial interest in the company. Terms of this arrangement have been reviewed and approved by UC Irvine in accordance with its conflict of interest policies. ",
year = "2010",
month = nov,
day = "15",
doi = "10.1063/1.3495773",
language = "English",
volume = "97",
journal = "Applied Physics Letters",
issn = "0003-6951",
publisher = "American Institute of Physics",
number = "20",
}