Bilateral Facial Weakness with Distal Paresthesia Following COVID-19 Vaccination: A Scoping Review for an Atypical Variant of Guillain–Barré Syndrome

Yoo Hwan Kim, Jee Eun Kim, Byeol A. Yoon, Jong Kuk Kim, Jong Seok Bae

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background and Purpose: Recent population-based studies from the US and UK have identified an increase in the occurrence of Guillain–Barré syndrome (GBS) following coronavirus disease 2019 (COVID-19) vaccination. However, the localized variant of GBS might be underestimated due to its rarity and atypical features. We aimed to identify and characterize bilateral facial weakness with distal paresthesia (BFWdp) as a GBS variant following COVID-19 vaccination. Materials and Methods: Relevant studies published during the COVID-19 pandemic were searched and identified in the MEDLINE, Embase, and other databases. Results: This review found that 18 BFWdp cases presented characteristics similar to previous BFWdp cases as defined in the literature: male dominance, frequent albuminocytological dissociation, and acute inflammatory demyelinating neuropathy pattern. In contrast, facial nerve enhancement on brain MRI and antiganglioside antibody positivity were often observed in BFWdp following COVID-19 vaccination. Conclusions: The mechanism of BFWdp following COVID-19 vaccination appears to be somewhat different from that of sporadic BFWdp. Neurological syndromes with rare incidence and difficulty in diagnosis should be considered adverse events of COVID-19 vaccination.

Original languageEnglish
Article number1046
JournalBrain Sciences
Volume12
Issue number8
DOIs
StatePublished - Aug 2022

Bibliographical note

Funding Information:
This study was supported by grant no. 2020-16 from the Kangdong Sacred Heart Hospital Fund (J.-S.B.).

Publisher Copyright:
© 2022 by the authors.

Keywords

  • adverse effects
  • COVID-19 vaccine
  • facial paralysis
  • Guillain–Barré syndrome
  • systematic review

Fingerprint

Dive into the research topics of 'Bilateral Facial Weakness with Distal Paresthesia Following COVID-19 Vaccination: A Scoping Review for an Atypical Variant of Guillain–Barré Syndrome'. Together they form a unique fingerprint.

Cite this