Baseline Cohort Profile of the Korean Chronic Cough Registry: A Multicenter, Prospective, Observational Study

Eun Jung Jo, Ji Hyang Lee, Ha Kyeong Won, Noeul Kang, Sung Yoon Kang, Seung Eun Lee, Ji Ho Lee, Mi Yeong Kim, Ji Su Shim, Jin An, Youngsang Yoo, So Young Park, Byung Keun Kim, Ji Yong Moon, Han Ki Park, Min Hye Kim, Hyouk Soo Kwon, Sae Hoon Kim, Sang Heon Kim, Yoon Seok ChangSang Hoon Kim, Surinder S. Birring, Byung Jae Lee, Woo Jung Song

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Purpose: The Korean Chronic Cough Registry study was initiated to characterize patients with chronic cough (CC) and investigate their outcomes in real-world clinical practice. This report aims to describe the baseline cohort profile and study protocols. Methods: This multicenter, prospective observational cohort study included newly referred CC patients and those already being treated for refractory or unexplained chronic cough (RUCC). Cough status was assessed using a visual analog scale, the Leicester Cough Questionnaire (LCQ), and the Cough Hypersensitivity Questionnaire (CHQ). Results: A total of 610 patients (66.9% women; median age 59.0 years) were recruited from 18 centers, with 176 being RUCC patients (28.9%). The median age at CC onset was 50.1 years, and 94.4% had adult-onset CC (≥ 19 years). The median cough duration was 4 years. Compared to newly referred CC patients, RUCC patients had a longer cough duration (6.0 years vs. 3.0 years) but had fewer symptoms and signs suggesting asthma, rhinosinusitis, or gastroesophageal acid reflux disease. Subjects with RUCC had lower LCQ scores (10.3 ± 3.3 vs. 11.6 ± 3.6; P < 0.001) and higher CHQ scores (9.1 ± 3.9 vs. 8.4 ± 4.1; P = 0.024). There were no marked differences in the characteristics of cough between refractory chronic cough and unexplained chronic cough. Conclusions: Chronic cough typically develops in adulthood, lasting for years. Cough severity and quality of life impairment indicate the presence of unmet clinical needs and insufficient cough control in real-world clinical practice. Longitudinal follow-up is warranted to investigate the natural history and treatment outcomes.

Original languageEnglish
Pages (from-to)477-488
Number of pages12
Issue number5
StatePublished - Oct 2023

Bibliographical note

Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.


  • Cough
  • Patient outcome assessment
  • Prospective studies
  • Registries


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