Background Colonic 18F-Fluoro-2-Deoxy-D-Glucose uptake on positron emission tomography is associated with the presence of colorectal adenoma

Ko Eun Lee, Chang Mo Moon, Hai Jeon Yoon, Bom Sahn Kim, Ji Young Chang, Hyo Moon Son, Min Sun Ryu, Seong Eun Kim, Ki Nam Shim, Hye Kyung Jung, Sung Ae Jung

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

18F-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) scan is used to evaluate various kinds of tumors. While most studies on PET findings of the colon focus on the colonic uptake pattern, studies regarding background colonic uptake on PET scan are rare. The purpose of this study was to identify the association between the background colonic uptake and the presence of colorectal adenoma (CRA), which is a frequent precancerous lesion. We retrospectively reviewed the medical records of 241 patients with gynecologic malignancy who had received PET or PET/computed tomography (CT) scan and colonoscopy at the same period as a baseline evaluation. Background colonic 18F-FDG uptake was visually graded and the maximal standardized uptake values (SUVmax ) of 7 different bowel segments were averaged. In univariate analysis, older age at diagnosis ( 50 years, p = 0.034), overweight (BMI ≥ 23 kg/m?, p = 0.010), hypercholesterolemia ( 200 mg/dL, p = 0.027), and high grade background colonic uptake (p = 0.009) were positively associated with the prevalence of CRA. By multiple logistic regression, high grade background colonic uptake was independently predictive of CRA (odds ratio = 2.25, p = 0.021). The proportion of CRA patients significantly increased as background colonic uptake grade increased from 1 to 4 (trend p = 0.015). Out of the 138 patients who underwent PET/CT, the proportion of CRA patients in the group with high SUVmax (> 2.25) was significantly higher than in the low SUVmax group (27.5% vs. 11.6%, p = 0.031). In conclusion, high grade of background colonic 18F-FDG uptake is significantly associated with the prevalence of CRA.

Original languageEnglish
Article numbere0160886
JournalPLoS ONE
Volume11
Issue number8
DOIs
StatePublished - Aug 2016

Fingerprint

Dive into the research topics of 'Background Colonic 18F-Fluoro-2-Deoxy-D-Glucose uptake on positron emission tomography is associated with the presence of colorectal adenoma'. Together they form a unique fingerprint.

Cite this