Augmented death in immunostimulated astrocytes deprived of glucose: Inhibition by an iron porphyrin FeTMPyP

In Young Choi, Sun Jung Lee, Wonwoo Nam, Jong Sun Park, Kwang Ho Ko, Hyoung Chun Kim, Chan Young Shin, Jang Hyun Chung, Seo Kyu Noh, Chang Rak Choi, Dong Hoon Shin, Won Ki Kim

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16 Scopus citations


The present study shows that under glucose-deprived conditions immunostimulated astrocytes rapidly undergo death due to their increased susceptibility to endogenously produced peroxynitrite. Fe(III)tetrakis(N-methyl-4'-pyridyl)porphyrin (FeTMPyP), but not the structurally related compounds ZnTMPyP and H2TMPyP, prevented the death in glucose-deprived immunostimulated astrocytes. Consistently, FeTMPyP, not ZnTMPyP and H2TMPyP, completely blocked the elevation of nitrotyrosine immunoreactivity (a marker of peroxynitrite) and the depolarization of the mitochondrial transmembrane potential in glucose-deprived immunostimulated astrocytes. The present data suggest that peroxynitrite may be associated with glial cell death during metabolic deterioration in the cerebral ischemic penumbra. (C) 2001 Published by Elsevier Science B.V.

Original languageEnglish
Pages (from-to)55-62
Number of pages8
JournalJournal of Neuroimmunology
Issue number1-2
StatePublished - 1 Jan 2001

Bibliographical note

Funding Information:
This work was supported by a grant from the Korea Research Foundation (1998) and a grant (#1999-2-207-007-3) of the Korea Science and Engineering Foundation, Republic of Korea. I.Y.C. and S.J.L. are the recipients of Research Fellowship (Brain Korea 21 Project).


  • Astrocyte
  • FeTMPyP
  • Glucose deprivation
  • Mitochondria transmembrane potential
  • Peroxynitrite


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