Atypical basal ganglia germinoma presenting as cerebral hemiatrophy: Diagnosis and follow-up with 11C-methionine positron emission tomography

Jeehun Lee, Bo Lyun Lee, Keon Hee Yoo, Ki Woong Sung, Hong Hoe Koo, Su Jin Lee, Joon Young Choi, Kyung Han Lee, Jung Il Lee, Hyung Jin Shin, Ji Hye Kim, Yeon Lim Suh, Ke Hyang Lee, Munhyang Lee

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Objects: Some basal ganglia germinomas are difficult to diagnose in early stage of disease due to vague initial presentation without discernable mass lesion on brain imaging. We performed this study to determine the usefulness of 11C-methionine positron emission tomography (MET PET) for the diagnosis and monitoring of disease activity. Materials and methods: MET PET was performed in three consecutive patients; they presented with cerebral hemiatrophy without definite mass lesions on brain image. The maximum standard tracer uptake values (max SUVs) were calculated and used for the quantitative evaluation of the abnormal MET uptake. A pathological diagnosis was made after stereotactic biopsy using MET PET/computed tomography. The max SUVs significantly decreased after treatment. Conclusion: Basal ganglia germinoma should be considered in the differential diagnosis of patients with progressive hemiparesis and hemiatrophy on magnetic resonance imaging. The MET PET was useful for diagnosis, and it can be valuable in evaluation of treatment effects and monitoring for tumor recurrence.

Original languageEnglish
Pages (from-to)29-37
Number of pages9
JournalChild's Nervous System
Volume25
Issue number1
DOIs
StatePublished - 2009

Keywords

  • C-Methionine positron emission tomography
  • Basal ganglia
  • Cerebral hemiatrophy
  • Germinoma
  • Progressive hemiparesis
  • Stereotactic biopsy

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