Asymmetrically altered integrity of cingulum bundle in posttraumatic stress disorder

Seog Ju Kim, Do Un Jeong, Minyoung E. Sim, Soojeong C. Bae, Ain Chung, Minue J. Kim, Kee Hyun Chang, Jeong Ryu, Perry F. Renshaw, In Kyoon Lyoo

Research output: Contribution to journalArticlepeer-review

84 Scopus citations


Previously, our group reported the altered white matter tract integrity of the left anterior cingulate in posttraumatic stress disorder (PTSD) in whole-brain exploration. Current study intended to explore whether the alteration was more prominent in any specific regions of the cingulum bundle. Diffusion tensor images of 21 PTSD subjects and 21 healthy comparison subjects were acquired. Eight isocubic regions of interest (ROIs), i.e. bilateral rostral, subgenual, dorsal, and upper cingulum bundle, were selected. Fractional anisotropy values in each ROI, which indicate the white matter tract integrity, were measured and compared between groups. Relative to comparison subjects, PTSD subjects had significantly smaller fractional anisotropy values in the left side of rostral, subgenual and dorsal cingulum bundle (26.7, 25.0, 22.2% decrease, respectively), but not in the right side ROIs. We report an asymmetrical alteration of the cingulum bundle in PTSD.

Original languageEnglish
Pages (from-to)120-125
Number of pages6
Issue number2
StatePublished - Jan 2007


  • Anterior cingulate gyrus
  • Cingulum bundle
  • Posttraumatic stress disorder


Dive into the research topics of 'Asymmetrically altered integrity of cingulum bundle in posttraumatic stress disorder'. Together they form a unique fingerprint.

Cite this