@article{8747c0a0f4ab404c913e85eecfae2f4e,
title = "Asymmetric Total Syntheses of Kopsane Alkaloids via a PtCl2-Catalyzed Intramolecular [3+2] Cycloaddition",
abstract = "A concise and asymmetric total synthesis of five kopsane alkaloids that share a unique heptacyclic caged ring system was accomplished. The key transformation in the sequence involved a remarkable PtCl2-catalyzed intramolecular [3+2] cycloaddition, which allowed for the rapid assembly of pentacyclic carbon skeletons bearing 2,3-quaternary functionalized indoline. Expeditious construction of diverse indoline scaffolds with excellent control of diastereoselectivity demonstrated the broad scope and versatility of this key transformation.",
keywords = "Pt catalysis, [3+2] cycloaddition reactions, alkaloids, kopsanes, natural products",
author = "Xuelei Jia and Honghui Lei and Feipeng Han and Tao Zhang and Ying Chen and Zhengshuang Xu and Pratanphorn Nakliang and Sun Choi and Yian Guo and Tao Ye",
note = "Funding Information: We acknowledge financial support from the National Natural Science Foundation of China (21772009, 21901013), the Shenzhen Peacock Plan (KQTD2015071714043444), the Shenzhen Science and Technology Innovation Commission (JCYJ20170818090017617, JCYJ20170818090238288), the GDNSF (2014B030301003), the National Research Foundation of Korea (NRF) grants funded by the Ministry of Science and ICT (MSIT; NRF-2017R1A2B4010084, 2018R1A5A2025286, NRF-2019M3E5D4065251), and a Peng Cheng Scholar (to S.C.). Moreover, we thank the Korea Institute of Science and Technology Information (KISTI) Supercomputing Center for providing computing resources. This work was also inspired by the international and interdisciplinary environments of the JSPS Asian CORE Program, “Asian Chemical Biology Initiative”. Funding Information: We acknowledge financial support from the National Natural Science Foundation of China (21772009, 21901013), the Shenzhen Peacock Plan (KQTD2015071714043444), the Shenzhen Science and Technology Innovation Commission (JCYJ20170818090017617, JCYJ20170818090238288), the GDNSF (2014B030301003), the National Research Foundation of Korea (NRF) grants funded by the Ministry of Science and ICT (MSIT; NRF‐2017R1A2B4010084, 2018R1A5A2025286, NRF‐2019M3E5D4065251), and a Peng Cheng Scholar (to S.C.). Moreover, we thank the Korea Institute of Science and Technology Information (KISTI) Supercomputing Center for providing computing resources. This work was also inspired by the international and interdisciplinary environments of the JSPS Asian CORE Program, “Asian Chemical Biology Initiative”. Publisher Copyright: {\textcopyright} 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2020",
month = jul,
day = "27",
doi = "10.1002/anie.202005048",
language = "English",
volume = "59",
pages = "12832--12836",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "31",
}