Asymmetric synthesis of functionalized benzo[a]quinolizine derivatives via a diastereoselective N-acyliminium ion cyclization

Yong Sup Lee, Soo Sung Kang, Jung Hoon Choi, Hokoon Park

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

A chiral synthesis of functionalized benzo[a]quinolizine derivative (5) has been accomplished starting from a chiral lactone 7. The key feature is the efficient control of the stereochemistry of ring juncture of the functionalized benzo[a]quinolizine derivative 5 by the N-acyliminium ion cyclization of chiral lactam 11b.

Original languageEnglish
Pages (from-to)3045-3056
Number of pages12
JournalTetrahedron
Volume53
Issue number9
DOIs
StatePublished - 3 Mar 1997

Bibliographical note

Funding Information:
Acknowledgment. Financial support from the Korea Ministry of

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