@article{8cee8240f2a0455f93c3045bba29ca31,
title = "Asymmetric Synthesis of Fluoro-MLN4924 as a Selective NEDD8-Activating Enzyme (NAE) Inhibitor",
abstract = "Based on bioisosteric rationale, fluorinated analogues of MLN4924, which is a selective NEDD8-activating enzyme inhibitor, were designed and their asymmetric syntheses were accomplished via stereoselective reduction, regioselective isopropylidene cleavage and diethylaminosulfur trifluoride (DAST) fluorination as key steps.",
keywords = "Bioisotere, DAST fluorination, Fluoro-MLN4924, MLN4924, NEDD8 inhibitor",
author = "Kim, {Hong Rae} and Jarhad, {Dnyandev B.} and Sahu, {Pramod K.} and Kisu Sung and Dayoung An and Hyun, {Young Eum} and Jinha Yu and Jeong, {Lak Shin}",
note = "Funding Information: This work was supported by grants from Mid‐career Research Program (2016R1A2B3010164) and the Ministry of Science, ICT & Future Planning (2017M3A9A8032086) of the National Research Foundation (NRF), Korea. Funding Information: This work was supported by grants from Mid-career Research Program (2016R1A2B3010164) and the Ministry of Science, ICT & Future Planning (2017M3A9A8032086) of the National Research Foundation (NRF), Korea. Publisher Copyright: {\textcopyright} 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2019",
month = sep,
day = "1",
doi = "10.1002/ajoc.201900350",
language = "English",
volume = "8",
pages = "1641--1647",
journal = "Asian Journal of Organic Chemistry",
issn = "2193-5807",
publisher = "Wiley - VCH Verlag GmbH & CO. KGaA",
number = "9",
}