Asymmetric synthesis of cyclopropyl-fused 2′-C-methylcarbanucleosides as potential anti-HCV agents

Lak Shin Jeong; Jeong A. Lee; Hea Ok Kim; Dilip K. Tosh; Hyung Ryong Moon; Seung Jin Lee; Kang Man Lee; Yhun Y. Sheen; Moon Woo Chun

doi:10.1080/15257770701508612

Asymmetric synthesis of cyclopropyl-fused 2′-C-methylcarbanucleosides as potential anti-HCV agents

Lak Shin Jeong
, Jeong A. Lee
, Hea Ok Kim
, Dilip K. Tosh
, Hyung Ryong Moon
, Seung Jin Lee
, Kang Man Lee
, Yhun Y. Sheen
, Moon Woo Chun

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Novel 2′-C-methyl-cyclopropyl-fused carbocyclic nucleosides as potential anti-HCV agents were stereoselectively synthesized, utilizing regioselective cleavage of the isopropylidene group and cyclic sulfate chemistry as key steps.

Original language	English
Pages (from-to)	1021-1024
Number of pages	4
Journal	Nucleosides, Nucleotides and Nucleic Acids
Volume	26
Issue number	8-9
DOIs	https://doi.org/10.1080/15257770701508612
State	Published - Aug 2007

Bibliographical note

Funding Information:
This research was supported by a grant from the Korea Research Foundation (KRF-2005-005-J01502). Anti-HCV assay by Gilead Sciences is greatly appreciated. Address correspondence to Lak Shin Jeong, College of Pharmacy, Ewha Womans University, Seoul 120 750, Korea. E-mail: [email protected]

Keywords

Anti-HCV agents
Cyclic sulfate chemistry
Hepatitis C virus
Regioselective opening

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/15257770701508612

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title = "Asymmetric synthesis of cyclopropyl-fused 2′-C-methylcarbanucleosides as potential anti-HCV agents",

abstract = "Novel 2′-C-methyl-cyclopropyl-fused carbocyclic nucleosides as potential anti-HCV agents were stereoselectively synthesized, utilizing regioselective cleavage of the isopropylidene group and cyclic sulfate chemistry as key steps.",

keywords = "Anti-HCV agents, Cyclic sulfate chemistry, Hepatitis C virus, Regioselective opening",

author = "Jeong, \{Lak Shin\} and Lee, \{Jeong A.\} and Kim, \{Hea Ok\} and Tosh, \{Dilip K.\} and Moon, \{Hyung Ryong\} and Lee, \{Seung Jin\} and Lee, \{Kang Man\} and Sheen, \{Yhun Y.\} and Chun, \{Moon Woo\}",

note = "Funding Information: This research was supported by a grant from the Korea Research Foundation (KRF-2005-005-J01502). Anti-HCV assay by Gilead Sciences is greatly appreciated. Address correspondence to Lak Shin Jeong, College of Pharmacy, Ewha Womans University, Seoul 120 750, Korea. E-mail: [email protected]",

year = "2007",

month = aug,

doi = "10.1080/15257770701508612",

language = "English",

volume = "26",

pages = "1021--1024",

journal = "Nucleosides, Nucleotides and Nucleic Acids",

issn = "1525-7770",

publisher = "Taylor and Francis Ltd.",

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TY - JOUR

T1 - Asymmetric synthesis of cyclopropyl-fused 2′-C-methylcarbanucleosides as potential anti-HCV agents

AU - Jeong, Lak Shin

AU - Lee, Jeong A.

AU - Kim, Hea Ok

AU - Tosh, Dilip K.

AU - Moon, Hyung Ryong

AU - Lee, Seung Jin

AU - Lee, Kang Man

AU - Sheen, Yhun Y.

AU - Chun, Moon Woo

N1 - Funding Information: This research was supported by a grant from the Korea Research Foundation (KRF-2005-005-J01502). Anti-HCV assay by Gilead Sciences is greatly appreciated. Address correspondence to Lak Shin Jeong, College of Pharmacy, Ewha Womans University, Seoul 120 750, Korea. E-mail: [email protected]

PY - 2007/8

Y1 - 2007/8

N2 - Novel 2′-C-methyl-cyclopropyl-fused carbocyclic nucleosides as potential anti-HCV agents were stereoselectively synthesized, utilizing regioselective cleavage of the isopropylidene group and cyclic sulfate chemistry as key steps.

AB - Novel 2′-C-methyl-cyclopropyl-fused carbocyclic nucleosides as potential anti-HCV agents were stereoselectively synthesized, utilizing regioselective cleavage of the isopropylidene group and cyclic sulfate chemistry as key steps.

KW - Anti-HCV agents

KW - Cyclic sulfate chemistry

KW - Hepatitis C virus

KW - Regioselective opening

UR - https://www.scopus.com/pages/publications/36849002829

U2 - 10.1080/15257770701508612

DO - 10.1080/15257770701508612

M3 - Article

C2 - 18058529

AN - SCOPUS:36849002829

SN - 1525-7770

VL - 26

SP - 1021

EP - 1024

JO - Nucleosides, Nucleotides and Nucleic Acids

JF - Nucleosides, Nucleotides and Nucleic Acids

IS - 8-9

ER -

Asymmetric synthesis of cyclopropyl-fused 2′-C-methylcarbanucleosides as potential anti-HCV agents

Abstract

Bibliographical note

Keywords

UN SDGs

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