Novel 2′-C-methyl-cyclopropyl-fused carbocyclic nucleosides as potential anti-HCV agents were stereoselectively synthesized, utilizing regioselective cleavage of the isopropylidene group and cyclic sulfate chemistry as key steps.
Bibliographical noteFunding Information:
This research was supported by a grant from the Korea Research Foundation (KRF-2005-005-J01502). Anti-HCV assay by Gilead Sciences is greatly appreciated. Address correspondence to Lak Shin Jeong, College of Pharmacy, Ewha Womans University, Seoul 120 750, Korea. E-mail: email@example.com
- Anti-HCV agents
- Cyclic sulfate chemistry
- Hepatitis C virus
- Regioselective opening