Asymmetric synthesis of cyclopropyl-fused 2′-C-methylcarbanucleosides as potential anti-HCV agents

Lak Shin Jeong, Jeong A. Lee, Hea Ok Kim, Dilip K. Tosh, Hyung Ryong Moon, Seung Jin Lee, Kang Man Lee, Yhun Y. Sheen, Moon Woo Chun

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Novel 2′-C-methyl-cyclopropyl-fused carbocyclic nucleosides as potential anti-HCV agents were stereoselectively synthesized, utilizing regioselective cleavage of the isopropylidene group and cyclic sulfate chemistry as key steps.

Original languageEnglish
Pages (from-to)1021-1024
Number of pages4
JournalNucleosides, Nucleotides and Nucleic Acids
Volume26
Issue number8-9
DOIs
StatePublished - Aug 2007

Keywords

  • Anti-HCV agents
  • Cyclic sulfate chemistry
  • Hepatitis C virus
  • Regioselective opening

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