Asymmetric synthesis of cyclopropyl-fused 2′-C-methylcarbanucleosides as potential anti-HCV agents

Lak Shin Jeong; Jeong A. Lee; Hea Ok Kim; Dilip K. Tosh; Hyung Ryong Moon; Seung Jin Lee; Kang Man Lee; Yhun Y. Sheen; Moon Woo Chun

doi:10.1080/15257770701508612

Asymmetric synthesis of cyclopropyl-fused 2′-C-methylcarbanucleosides as potential anti-HCV agents

Lak Shin Jeong, Jeong A. Lee, Hea Ok Kim, Dilip K. Tosh, Hyung Ryong Moon, Seung Jin Lee, Kang Man Lee, Yhun Y. Sheen, Moon Woo Chun

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Novel 2′-C-methyl-cyclopropyl-fused carbocyclic nucleosides as potential anti-HCV agents were stereoselectively synthesized, utilizing regioselective cleavage of the isopropylidene group and cyclic sulfate chemistry as key steps.

Original language	English
Pages (from-to)	1021-1024
Number of pages	4
Journal	Nucleosides, Nucleotides and Nucleic Acids
Volume	26
Issue number	8-9
DOIs	https://doi.org/10.1080/15257770701508612
State	Published - Aug 2007

Bibliographical note

Funding Information:
This research was supported by a grant from the Korea Research Foundation (KRF-2005-005-J01502). Anti-HCV assay by Gilead Sciences is greatly appreciated. Address correspondence to Lak Shin Jeong, College of Pharmacy, Ewha Womans University, Seoul 120 750, Korea. E-mail: [email protected]

Keywords

Anti-HCV agents
Cyclic sulfate chemistry
Hepatitis C virus
Regioselective opening

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/15257770701508612

Cite this

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title = "Asymmetric synthesis of cyclopropyl-fused 2′-C-methylcarbanucleosides as potential anti-HCV agents",

abstract = "Novel 2′-C-methyl-cyclopropyl-fused carbocyclic nucleosides as potential anti-HCV agents were stereoselectively synthesized, utilizing regioselective cleavage of the isopropylidene group and cyclic sulfate chemistry as key steps.",

keywords = "Anti-HCV agents, Cyclic sulfate chemistry, Hepatitis C virus, Regioselective opening",

author = "Jeong, {Lak Shin} and Lee, {Jeong A.} and Kim, {Hea Ok} and Tosh, {Dilip K.} and Moon, {Hyung Ryong} and Lee, {Seung Jin} and Lee, {Kang Man} and Sheen, {Yhun Y.} and Chun, {Moon Woo}",

note = "Funding Information: This research was supported by a grant from the Korea Research Foundation (KRF-2005-005-J01502). Anti-HCV assay by Gilead Sciences is greatly appreciated. Address correspondence to Lak Shin Jeong, College of Pharmacy, Ewha Womans University, Seoul 120 750, Korea. E-mail: [email protected]",

year = "2007",

month = aug,

doi = "10.1080/15257770701508612",

language = "English",

volume = "26",

pages = "1021--1024",

journal = "Nucleosides, Nucleotides and Nucleic Acids",

issn = "1525-7770",

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T1 - Asymmetric synthesis of cyclopropyl-fused 2′-C-methylcarbanucleosides as potential anti-HCV agents

AU - Jeong, Lak Shin

AU - Lee, Jeong A.

AU - Kim, Hea Ok

AU - Tosh, Dilip K.

AU - Moon, Hyung Ryong

AU - Lee, Seung Jin

AU - Lee, Kang Man

AU - Sheen, Yhun Y.

AU - Chun, Moon Woo

N1 - Funding Information: This research was supported by a grant from the Korea Research Foundation (KRF-2005-005-J01502). Anti-HCV assay by Gilead Sciences is greatly appreciated. Address correspondence to Lak Shin Jeong, College of Pharmacy, Ewha Womans University, Seoul 120 750, Korea. E-mail: [email protected]

PY - 2007/8

Y1 - 2007/8

N2 - Novel 2′-C-methyl-cyclopropyl-fused carbocyclic nucleosides as potential anti-HCV agents were stereoselectively synthesized, utilizing regioselective cleavage of the isopropylidene group and cyclic sulfate chemistry as key steps.

AB - Novel 2′-C-methyl-cyclopropyl-fused carbocyclic nucleosides as potential anti-HCV agents were stereoselectively synthesized, utilizing regioselective cleavage of the isopropylidene group and cyclic sulfate chemistry as key steps.

KW - Anti-HCV agents

KW - Cyclic sulfate chemistry

KW - Hepatitis C virus

KW - Regioselective opening

UR - http://www.scopus.com/inward/record.url?scp=36849002829&partnerID=8YFLogxK

U2 - 10.1080/15257770701508612

DO - 10.1080/15257770701508612

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AN - SCOPUS:36849002829

SN - 1525-7770

VL - 26

SP - 1021

EP - 1024

JO - Nucleosides, Nucleotides and Nucleic Acids

JF - Nucleosides, Nucleotides and Nucleic Acids

IS - 8-9

ER -

Asymmetric synthesis of cyclopropyl-fused 2′-C-methylcarbanucleosides as potential anti-HCV agents

Abstract

Bibliographical note

Keywords

UN SDGs

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